[灭活自体多孔骨瓣与BAM骨诱导人工骨修复大鼠颅骨缺损的疗效]
[Efficacy of inactivated autologous porous bone flap and BAM bone-induced artificial bone for repairing skull defect in rats].
作者信息
Wang Chao-Min, Liu Tie-Jian, Song Zhen-Hua, Guo Xiao-Yu, Wei Da-Nian, Liu Cheng-Yong
机构信息
Treatment Center of Traumatic Injuries, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail:
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jun 20;38(6):748-754. doi: 10.3969/j.issn.1673-4254.2018.06.17.
OBJECTIVE
To study the effect of BAM bone grafting combined with inactivated autologous porous bone flap in repairing skull defect in rats.
METHODS
Seventy-two Wistar rats with skull defect were randomly divided into control group, inactivated autologous bone flap group (AB group), BAM bone-induced artificial bone material group (BAM group), and inactivated autologous bone flap with BAM bone-induced artificial bone group (BAM+AB group). The bone healing was evaluated with micro-CT and the new bone formation was assessed with histological staining at 1, 2, and 3 months after modeling.
RESULTS
Inactivated porous bone flap combined with BAM bone-induced artificial bone effectively induced vascular and fibrous tissue regeneration and osteogenesis in the cranial defects. With the inactivated porous bone flap as the scaffold, BAM bone-induced artificial bone obviously promoted the restoration of the skull appearance in the rats with cranial defects.
CONCLUSION
Inactivated autologous bone flap group and BAM bone-induced artificial bone material can promote skull healing and restoration of the original skull appearance, and can be used for reconstruction of the local anatomy of the skull surface.
目的
研究BAM骨移植联合灭活自体多孔骨瓣修复大鼠颅骨缺损的效果。
方法
将72只颅骨缺损的Wistar大鼠随机分为对照组、灭活自体骨瓣组（AB组）、BAM骨诱导人工骨材料组（BAM组）和BAM骨诱导人工骨联合灭活自体骨瓣组（BAM+AB组）。建模后1、2和3个月，用微型计算机断层扫描评估骨愈合情况，并用组织学染色评估新骨形成情况。
结果
灭活多孔骨瓣联合BAM骨诱导人工骨能有效诱导颅骨缺损处血管和纤维组织再生以及成骨。以灭活多孔骨瓣为支架，BAM骨诱导人工骨明显促进了颅骨缺损大鼠颅骨外观的恢复。
结论
灭活自体骨瓣组和BAM骨诱导人工骨材料可促进颅骨愈合和恢复原始颅骨外观，可用于颅骨表面局部解剖结构的重建。
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