Barbe Coralie, Morrone Isabelle, Wolak-Thierry Aurore, Dramé Moustapha, Jolly Damien, Novella Jean-Luc, Mahmoudi Rachid
a EA 3797 Faculté de Médecine , Université de Reims Champagne-Ardenne , Reims , France.
b Unité d'aide méthodologique , Pôle Recherche et innovations , CHU de Reims, Reims , France.
Aging Ment Health. 2017 May;21(5):571-576. doi: 10.1080/13607863.2015.1132674. Epub 2016 Jan 8.
To identify factors associated with health-related quality of life (HRQoL) as assessed by the Dementia Quality of Life (DQoL) in patients with Alzheimer's disease (AD), focusing particularly on functional alterations.
Cross-sectional multicenter study in subjects aged 65 years or older with mild to moderate AD. HRQoL was measured using the DQoL (five domains: self-esteem, positive affect/humor, negative affect, feeling of belonging, and sense of esthetics). Functional alterations were assessed based on activities of daily living (ADLs) and instrumental activities of daily living (IADLs). We also recorded socio-demographic characteristics of the patient and their carer, and comprehensive geriatric assessment including MMSE and psycho-behavioral data (Neuropsychiatric Inventory, Cornell depression score). Factors associated with each domain of the DQol were identified by multivariate linear regression.
In total, 123 subjects were included (mean age 82 ± 6 years, 64% women). Two of the five domains of the DQoL were significantly associated with factors based on functional evaluation. The ability to transfer within the home and the ability to use the telephone were associated with an increase in HRQoL in the 'self-esteem' domain (p = 0.02 and 0.05, respectively). Ability to get dressed without assistance was associated with lower HRQoL in the 'negative affect' domain (p = 0.0007).
Alterations in functional capacity have a significant effect on HRQoL in several domains of the DQoL.
确定阿尔茨海默病（AD）患者中与通过痴呆症生活质量量表（DQoL）评估的健康相关生活质量（HRQoL）相关的因素，尤其关注功能改变。
对65岁及以上患有轻度至中度AD的受试者进行横断面多中心研究。使用DQoL（五个领域：自尊、积极情感/幽默、消极情感、归属感和审美感）测量HRQoL。基于日常生活活动（ADL）和工具性日常生活活动（IADL）评估功能改变。我们还记录了患者及其照顾者的社会人口学特征，以及包括简易精神状态检查表（MMSE）和心理行为数据（神经精神科问卷、康奈尔抑郁评分）在内的综合老年评估。通过多变量线性回归确定与DQoL每个领域相关的因素。
总共纳入了123名受试者（平均年龄82±6岁，64%为女性）。DQoL的五个领域中有两个与基于功能评估的因素显著相关。在家中转移的能力和使用电话的能力与“自尊”领域的HRQoL增加相关（分别为p = 0.02和0.05）。无需协助就能穿衣的能力与“消极情感”领域较低的HRQoL相关（p = 0.0007）。
功能能力的改变对DQoL的几个领域中的HRQoL有显著影响。
