Barbe Coralie, Morrone Isabella, Novella J L, Dramé Moustapha, Wolak-Thierry Aurore, Aquino Jean-Pierre, Ankri Joël, Jolly Damien, Mahmoudi Rachid
Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, France; Department of Research and Public Health, Reims University Hospital, Reims, France.
Department of Geriatrics and Internal Medicine, Reims University Hospital, Reims, France.
Dement Geriatr Cogn Dis Extra. 2016 Dec 5;6(3):549-558. doi: 10.1159/000450975. eCollection 2016 Sep-Dec.
To determine predictive factors associated with rapid cognitive decline (RCD) in elderly patients suffering from Alzheimer disease (AD).
Patients suffering from mild to moderate AD were included. RCD was defined as the loss of at least 3 points on the Mini-Mental State Examination (MMSE) over 12 months. Factors associated with RCD were identified by logistic regression.
Among 123 patients included, 61 were followed up until 12 months. RCD occurred in 46% of patients ( = 28). Polymedication ( < 0.0001), the fact that the caregiver was the child or spouse of the patient ( < 0.0001) and autonomy for washing ( < 0.0001) were protective factors against RCD, while the presence of caregiver burden ( < 0.0001) was shown to be a risk factor for RCD.
Early detection of the RCD risk in AD patients could make it possible to anticipate the patient's medical needs and adjust the care plan for caregiver burden.
确定阿尔茨海默病（AD）老年患者快速认知衰退（RCD）的相关预测因素。
纳入轻至中度AD患者。RCD定义为在12个月内简易精神状态检查表（MMSE）评分至少下降3分。通过逻辑回归确定与RCD相关的因素。
在纳入的123例患者中，61例随访至12个月。46%的患者（n = 28）出现RCD。多重用药（P < 0.0001）、照顾者为患者的子女或配偶这一情况（P < 0.0001）以及自主洗漱能力（P < 0.0001）是RCD的保护因素，而存在照顾者负担（P < 0.0001）是RCD的危险因素。
早期发现AD患者的RCD风险有助于预测患者的医疗需求并针对照顾者负担调整护理计划。
