Ezenwaka Chidum E, Idris Saleh, Davis Gershwin, Roberts Lesley
a Department of Para-Clinical Sciences , Faculty of Medical Sciences, The University of the West Indies , St Augustine Campus , Trinidad and Tobago , and.
b National Organ Transplant Unit, Eric Williams Medical Science Complex , Mount Hope , Trinidad and Tobago.
Arch Physiol Biochem. 2016;122(2):70-4. doi: 10.3109/13813455.2016.1140212. Epub 2016 Feb 10.
Chronic kidney disease (CKD) is one of the major complication from non-communicable diseases (NCD), such as diabetes or hypertension. We aimed to determine if routine measurement of neutrophil gelatinase-associated lipocalin (NGAL) in NCD patients could provide additional benefit for diagnosing kidney disease.
Fasting serum NGAL, urea, creatinine, uric acid and albumin were measured in 298 NCD patients. Estimated glomerular filtration rate (e-GFR) was calculated using the CKD-EPI equation. Multiple linear regression modeling was used for analysis.
CKD patients have the highest levels of NGAL than the other NCD patients (p < 0.001). Although NGAL was significantly related to e-GFR, creatinine, urea and albumin in CKD-patients (p < 0.001) and not in the other NCD patients (p > 0.05), only serum creatinine predicted NGAL levels in CKD-patients (p < 0.001).
NGAL level is best associated with serum creatinine only in patients with CKD and NGAL measurement may not be cost effective as a routine kidney function test in NCD patients in under-resourced economies.
慢性肾脏病（CKD）是非传染性疾病（如糖尿病或高血压）的主要并发症之一。我们旨在确定对非传染性疾病患者常规检测中性粒细胞明胶酶相关脂质运载蛋白（NGAL）是否有助于诊断肾脏疾病。
对298例非传染性疾病患者测量空腹血清中的NGAL、尿素、肌酐、尿酸和白蛋白。采用慢性肾脏病流行病学合作（CKD-EPI）公式计算估计肾小球滤过率（e-GFR）。采用多元线性回归模型进行分析。
CKD患者的NGAL水平高于其他非传染性疾病患者（p<0.001）。虽然在CKD患者中NGAL与e-GFR、肌酐、尿素和白蛋白显著相关（p<0.001），而在其他非传染性疾病患者中无显著相关性（p>0.05），但在CKD患者中只有血清肌酐可预测NGAL水平（p<0.001）。
仅在CKD患者中，NGAL水平与血清肌酐密切相关，在资源匮乏地区，检测NGAL作为非传染性疾病患者的常规肾功能检查可能不具有成本效益。
