Daëron Marc
Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France; Centre d'immunologie de Marseille-Luminy, Université Aix Marseille UM2, Inserm U1104, CNRS UMR7280, 13288 Marseille, France.
Curr Opin Immunol. 2016 Feb;38:101-8. doi: 10.1016/j.coi.2015.12.004. Epub 2015 Dec 30.
Mast cells and basophils are mostly known as the initiators of IgE-dependent allergic reactions. They, however, contribute to innate immunity against pathogens and venoms. Like other myeloid cells, they also express receptors for the Fc portion of IgG antibodies. These include activating receptors and inhibitory receptors. Because IgG antibodies are produced in exceedingly higher amounts than IgE antibodies, IgG receptors are co-engaged with IgE receptors under physiological conditions. Mast cells and basophils are examples of the many innate myeloid cells whose effector functions are used and finely tuned by antibodies. They can be thus enrolled in a variety of adaptive immune responses, their activation can be regulated, positively and negatively and their biological responses can be modulated qualitatively by antibodies.
肥大细胞和嗜碱性粒细胞主要被认为是IgE依赖性过敏反应的引发者。然而，它们也有助于针对病原体和毒液的固有免疫。与其他髓样细胞一样，它们也表达IgG抗体Fc部分的受体。这些受体包括激活受体和抑制受体。由于IgG抗体的产生量比IgE抗体高得多，在生理条件下，IgG受体与IgE受体共同参与作用。肥大细胞和嗜碱性粒细胞是众多固有髓样细胞的例子，其效应功能被抗体利用并得到精细调节。因此，它们可以参与多种适应性免疫反应，其激活可以受到正向和负向调节，并且它们的生物学反应可以通过抗体进行定性调节。
