Olshansky Brian
Cardiac Electrophysiology, University of Iowa Hospitals, Iowa City, IA.
Trends Cardiovasc Med. 2016 Jan;26(1):1-11. doi: 10.1016/j.tcm.2015.03.016. Epub 2015 Apr 3.
The vagus nerve modulates inflammatory responses in various organ systems. Emerging evidence indicates that the vagus can have profound and complex effects on cardiovascular function, remodeling, arrhythmias, and mortality by several mechanisms. In heart failure and during ischemia, an adverse inflammatory response can occur. The vagus nerve may modulate cardiovascular disease and outcomes by affecting inflammatory responses. Here, evidence for and components of the vagus inflammatory reflex are reviewed and evidence for and implications of effects of vagus activation on inflammation in the cardiovascular system are considered.
迷走神经调节各个器官系统中的炎症反应。新出现的证据表明，迷走神经可通过多种机制对心血管功能、重塑、心律失常及死亡率产生深远而复杂的影响。在心力衰竭和缺血期间，可能会发生不良炎症反应。迷走神经可能通过影响炎症反应来调节心血管疾病及其转归。本文综述了迷走神经炎症反射的证据及组成部分，并探讨了迷走神经激活对心血管系统炎症影响的证据及意义。
