Rush Barret, Rousseau Justin, Sekhon Mypinder S, Griesdale Donald E
Division of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts; Center for Evidence-Based Imaging, Brigham and Women's Hospital, Boston, Massachusetts.
World Neurosurg. 2016 Apr;88:25-31. doi: 10.1016/j.wneu.2015.12.034. Epub 2015 Dec 31.
The optimal surgical management of acute traumatic subdural hematoma (ASDH) is controversial; both craniectomy and craniotomy are performed. The purpose of this study was to determine the current management of ASDH in the United States.
This retrospective cohort study used the Nationwide Inpatient Sample from the years 2006-2011 to examine patients with a primary diagnosis of ASDH. All patients ≥18 years old with a primary diagnosis of ASDH were included in the analysis. Patients with procedure codes for craniectomy and craniotomy were isolated from the database. Propensity score matching based on logistic regression was used to match craniotomy to craniectomy in a 1:1 fashion.
There were 47,911,414 hospitalizations analyzed. Of 60,435 patients with ASDH identified, 1763 underwent craniotomy and 177 underwent craniectomy. The average age of patients who underwent craniectomy was 49.5 years (SD 20.8) compared with an average age of 68.9 years (SD 17.1) of patients who underwent craniotomy (P < 0.0001). Hospital mortality was significantly higher in patients who underwent craniectomy (35.0% vs. 10.9%, P < 0.0001). Patients who underwent craniectomy had longer hospital stays compared with patients who underwent craniotomy (median duration 14.3 days [interquartile range 25] for craniectomy vs. 10.9 days [interquartile range 9] for craniotomy, P < 0.0001). Patients who underwent craniectomy were also more likely to be discharged to a skilled nursing or rehabilitation facility (79.1% vs. 63.9%, P = 0.0011).
Craniotomy is the preferred surgical technique for management of ASDH in the United States, being performed 10 times more frequently than craniectomy. Craniectomy was associated with significantly higher in-hospital mortality after propensity score matched analysis.
急性创伤性硬膜下血肿(ASDH)的最佳手术治疗方法存在争议;颅骨切除术和开颅手术均有应用。本研究的目的是确定美国目前对ASDH的治疗方式。
这项回顾性队列研究使用了2006 - 2011年的全国住院患者样本,以检查原发性诊断为ASDH的患者。所有年龄≥18岁且原发性诊断为ASDH的患者均纳入分析。从数据库中分离出具有颅骨切除术和开颅手术程序代码的患者。基于逻辑回归的倾向评分匹配用于以1:1的方式将开颅手术与颅骨切除术进行匹配。
共分析了47,911,414例住院病例。在60,435例确诊为ASDH的患者中,1763例行开颅手术,177例行颅骨切除术。接受颅骨切除术的患者平均年龄为49.5岁(标准差20.8),而行开颅手术的患者平均年龄为68.9岁(标准差17.1)(P < 0.0001)。接受颅骨切除术的患者医院死亡率显著更高(35.0%对10.9%,P < 0.0001)。与接受开颅手术的患者相比,接受颅骨切除术的患者住院时间更长(颅骨切除术的中位持续时间为14.3天[四分位间距25],开颅手术为10.9天[四分位间距9],P < 0.0001)。接受颅骨切除术的患者也更有可能被转至专业护理或康复机构(79.1%对63.9%,P = 0.0011)。
在美国,开颅手术是治疗ASDH的首选手术技术,其实施频率比颅骨切除术高10倍。倾向评分匹配分析后发现,颅骨切除术与显著更高的院内死亡率相关。