Parsons Brendon, Foley Edan
1B3.14, 8440-112 Street, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB, T6G 2J2, Canada.
University of Alberta, Department of Medical Microbiology and Immunology, Canada.
Dev Comp Immunol. 2016 May;58:95-101. doi: 10.1016/j.dci.2015.12.019. Epub 2015 Dec 31.
Drosophila melanogaster is a widely used model for the characterization of blood cell development and function, with an array of protocols for the manipulation and visualization of fixed or live cells in vitro or in vivo. Researchers have deployed these techniques to reveal Drosophila hemocytes as a remarkably versatile cell type that engulfs apoptotic corpses; neutralizes invading parasites; seals epithelial wounds; and deposits extracellular matrix proteins. In this review, we will discuss the key features of Drosophila hemocyte development and function, and identify similarities with vertebrate counterparts.
黑腹果蝇是一种广泛用于表征血细胞发育和功能的模型，有一系列用于体外或体内固定或活细胞操作及可视化的方案。研究人员已运用这些技术揭示果蝇血细胞是一种非常多功能的细胞类型，它能吞噬凋亡尸体；中和入侵的寄生虫；封闭上皮伤口；并沉积细胞外基质蛋白。在这篇综述中，我们将讨论果蝇血细胞发育和功能的关键特征，并确定与脊椎动物对应物的相似之处。
