Department of Chemistry, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Republic of Korea.
Center for Self-assembly and Complexity, Institute for Basic Science, 77 Cheongam-ro, Nam-gu, Pohang 790-784, Republic of Korea.
Adv Drug Deliv Rev. 2016 Mar 1;98:99-112. doi: 10.1016/j.addr.2015.12.018. Epub 2015 Dec 31.
To date, various nanomaterials with the ability for gene delivery or photothermal effect have been developed in the field of biomedicine. The therapeutic potential of these nanomaterials has raised considerable interests in their use in potential next-generation strategies for effective anticancer therapy. In particular, the advancement of novel nanomedicines utilizing both therapeutic strategies of gene delivery and photothermal effect has generated much optimism regarding the imminent development of effective and successful cancer treatments. In this review, we discuss current research progress with regard to combined gene and photothermal therapy. This review focuses on synergistic therapeutic systems combining gene regulation and photothermal ablation as well as logically designed nano-carriers aimed at enhancing the delivery efficiency of therapeutic genes using the photothermal effect. The examples detailed in this review provide insight to further our understanding of combinatorial gene and photothermal therapy, thus paving the way for the design of promising nanomedicines.
迄今为止，在生物医药领域已经开发出了具有基因传递或光热效应的各种纳米材料。这些纳米材料的治疗潜力引起了人们极大的兴趣，认为它们可能成为下一代有效抗癌治疗策略的潜在应用。特别是，利用基因传递和光热效应这两种治疗策略的新型纳米药物的发展，为开发有效和成功的癌症治疗方法带来了极大的希望。在这篇综述中，我们讨论了联合基因和光热治疗的最新研究进展。本综述重点介绍了将基因调控与光热消融相结合的协同治疗系统，以及逻辑设计的纳米载体，旨在利用光热效应提高治疗基因的递送效率。本综述中详细介绍的实例为进一步了解组合基因和光热治疗提供了思路，为设计有前途的纳米药物铺平了道路。
