Zhu Hanjing, Yang Wei, Suo Yijun, Liu Ye, Zhan Xinyi, Zhou Jun, Chen Zhiying, Wu Xiangbing, Yin Xiaoping, Bao Bing
Department of Neurology, Affiliated Hospital of Jiujiang University, Jiujiang, China.
Front Bioeng Biotechnol. 2025 Jul 21;13:1631627. doi: 10.3389/fbioe.2025.1631627. eCollection 2025.
The rising incidence of neural tumors and neurodegenerative diseases cause significant health, emotional, and financial burdens. Conventional treatments like surgery and chemotherapy often lack effectiveness. However, advancements in nanotechnology, particularly photothermal therapy (PTT), offer new hope. PTT is widely studied for neural tumors and neurodegenerative diseases due to its simplicity, rapid recovery, combined therapeutic potential, and compatibility with imaging techniques. This innovative approach could revolutionize the diagnosis and treatment of neural tumors and neurodegenerative diseases, addressing current limitations and improving outcomes. In this article, we offer a comprehensive overview of the rational design and engineering of various nanomaterials designed specifically for PTT applications in neural tumors and neurodegenerative diseases, including organic platforms such as liposomes, dopamine, etc. and inorganic platforms such as gold nanomaterials, carbon nanomaterials, etc. A comparative analysis of these platforms examines their biocompatibility and potential for biodegradation. It also assesses their manufacturing scalability, cost-effectiveness, regulatory challenges, and ultimate potential for clinical translation. We also update the therapeutic advances of PTT in neural tumors (Glioma, Peripheral nerve sheath tumors, Spinal metastases from tumors and brain metastases) and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease), and systematically summarize the mechanisms of PTT application in neural tumors and neurodegenerative diseases. In the end, we provide an in-depth discussion of the advantages and disadvantages of PTT and the perspectives for its application in the above neurological disorders.
神经肿瘤和神经退行性疾病发病率的不断上升给健康、情感和经济带来了沉重负担。手术和化疗等传统治疗方法往往效果不佳。然而，纳米技术的进步，特别是光热疗法（PTT），带来了新的希望。由于其操作简单、恢复迅速、具有联合治疗潜力以及与成像技术的兼容性，PTT在神经肿瘤和神经退行性疾病方面得到了广泛研究。这种创新方法可能会彻底改变神经肿瘤和神经退行性疾病的诊断和治疗方式，克服当前的局限性并改善治疗效果。在本文中，我们全面概述了专门为神经肿瘤和神经退行性疾病的PTT应用而设计的各种纳米材料的合理设计与工程，包括脂质体、多巴胺等有机平台以及金纳米材料、碳纳米材料等无机平台。对这些平台的比较分析考察了它们的生物相容性和生物降解潜力。还评估了它们的生产可扩展性、成本效益、监管挑战以及临床转化的最终潜力。我们还更新了PTT在神经肿瘤（胶质瘤、周围神经鞘瘤、肿瘤脊髓转移和脑转移）和神经退行性疾病（阿尔茨海默病、帕金森病、亨廷顿病）中的治疗进展，并系统总结了PTT在神经肿瘤和神经退行性疾病中的应用机制。最后，我们深入讨论了PTT的优缺点及其在上述神经系统疾病中的应用前景。
