Wu Xixi, Liang Huazhen, Li Chaoming, Zhou Duanyang, Liu Rui
Department of Radiation Oncology, The People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530000 China.
The First Tumor Department, Maoming People's Hospital Maoming 525000 China.
RSC Adv. 2023 Oct 4;13(41):29061-29069. doi: 10.1039/d3ra04779b. eCollection 2023 Sep 26.
The specific tumor microenvironment is a conducive breeding ground for malignant tumors, favoring their survival, rapid proliferation, and metastasis, which is also an inevitable obstacle to tumor treatment, particularly for catalytic therapy. To address this issue, a hyperthermia-enhanced nanocatalyst (AuP@MnO) consisting of an asymmetric Au@polypyrrole core and a MnO shell is constructed for synergistic cancer Fenton/photothermal therapy. In an ultra-short reaction time (15 min), the innovative introduction of a new oxidizer, tetrachloroauric acid trihydrate, not only successfully initiates the oxidative polymerization of pyrrole monomer while reducing itself to cubic Au, but also accelerates the polymerization process by supplying protic acid. After MnO coating, AuP@MnO catalyzes the conversion of antioxidant GSH and excess HO into GSSG and ˙OH through Mn/Mn ion couples, leading to oxidative damage of tumor cells. More importantly, after 1064 nm laser irradiation, more extreme oxidative imbalance and cell death are demonstrated in this work under the combined effect of photothermal and catalytic therapy, with insignificant toxicity to normal cells. This work develops an efficient one-step synthesis method of asymmetric Au@polypyrrole and provides constructive insight into its oxidative stress-based antitumor treatment.
特定的肿瘤微环境是恶性肿瘤滋生的有利温床，有利于其存活、快速增殖和转移，这也是肿瘤治疗尤其是催化治疗不可避免的障碍。为了解决这个问题，构建了一种由不对称的金@聚吡咯核和二氧化锰壳组成的热增强纳米催化剂（AuP@MnO）用于协同癌症芬顿/光热治疗。在超短反应时间（15分钟）内，创新地引入新的氧化剂三水合四氯金酸，不仅成功引发吡咯单体的氧化聚合同时将自身还原为立方金，还通过提供质子酸加速聚合过程。在包覆二氧化锰后，AuP@MnO通过锰/锰离子对催化抗氧化剂谷胱甘肽（GSH）和过量的过氧化氢（HO）转化为氧化型谷胱甘肽（GSSG）和羟基自由基（˙OH），导致肿瘤细胞的氧化损伤。更重要的是，在1064纳米激光照射后，本研究表明在光热和催化治疗的联合作用下会出现更严重的氧化失衡和细胞死亡，而对正常细胞的毒性不明显。这项工作开发了一种高效的不对称金@聚吡咯一步合成方法，并为基于氧化应激的抗肿瘤治疗提供了建设性的见解。
