Moore-Morris Thomas, Cattaneo Paola, Puceat Michel, Evans Sylvia M
INSERM UMRS_910, Aix-Marseille Université, Marseille, France.
Skaggs School of Pharmacy, UCSD, La Jolla, CA, USA.
J Mol Cell Cardiol. 2016 Feb;91:1-5. doi: 10.1016/j.yjmcc.2015.12.031. Epub 2015 Dec 31.
Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as heart failure involving fibrosis. Cardiac fibroblasts have long remained a poorly characterized cardiac lineage. Well characterized markers are now paving the way for a better understanding of the roles of these cells in various developmental and disease contexts. Notably, the relevance of processes including endothelial-tomesenchymal transition and the recruitment of circulating fibroblast progenitors in heart failure has been challenged. This review describes the latest findings on cardiac fibroblast markers and developmental origins, and discusses their importance in myocardial remodeling. Effective modulation of cardiac fibroblast activity would likely contribute to successful treatment of various cardiac disorders.
心脏成纤维细胞产生细胞外基质（ECM）支架，心脏的各种细胞成分在该支架中有序排列。除了提供结构支持外，越来越明显的是，ECM的质量和数量是决定心脏细胞在发育过程中以及在诸如涉及纤维化的心力衰竭等病理情况下行为的关键因素。长期以来，心脏成纤维细胞一直是特征不明的心脏细胞谱系。现在，特征明确的标志物为更好地理解这些细胞在各种发育和疾病情况下的作用铺平了道路。值得注意的是，包括内皮-间充质转化和循环成纤维细胞祖细胞在心力衰竭中的募集等过程的相关性受到了挑战。本综述描述了关于心脏成纤维细胞标志物和发育起源的最新发现，并讨论了它们在心肌重塑中的重要性。有效调节心脏成纤维细胞活性可能有助于成功治疗各种心脏疾病。
