Kuliev A M, Andrianov V L, Kolpakova L V, Bolabovko A E
Ortop Travmatol Protez. 1989 May(5):45-7.
The authors have carried out an experimental study of demineralized osteochondrous allocaps (DOCA) for the arthroplasty of the hip joint. The articular cartilage was removed completely in 10, partly from the head in 5 and from the entire cavity in 2 of the 15 rabbits. The animals were excluded from the experiment at various terms (from 2 weeks to 10 months). It has been morphologically determined that when DOCA were employed, the regeneration of the articular cartilage of the head was most complete in cases of its focal resection. When the articular cartilage of the head was completely removed, the cartilaginous regenerate did not possess the mechanical properties of the normal one and was subjected to secondary degenerative and dystrophic changes. The best results were obtained in cases when plasty of the cavity with DOCA was performed. The signs of regeneration of the cartilage under the DOCA and its absence on the surface without the caps testify to chondroinductive properties of DOCA.
作者对脱矿骨软骨同种异体移植物（DOCA）用于髋关节置换术进行了实验研究。15只兔子中，10只的关节软骨被完全切除，5只的部分关节软骨从股骨头切除，2只的整个关节腔软骨被切除。这些动物在不同时期（从2周到10个月）被排除在实验之外。形态学研究表明，使用DOCA时，股骨头关节软骨局灶性切除的情况下再生最为完全。当股骨头关节软骨被完全切除时，软骨再生组织不具备正常软骨的力学性能，并会发生继发性退行性和营养不良性改变。当用DOCA进行关节腔成形术时，效果最佳。DOCA下方软骨的再生迹象以及无移植物覆盖表面的软骨无再生迹象，证明了DOCA具有软骨诱导特性。
