Kuliev A M, Kolpakova L V
Ortop Travmatol Protez. 1989 Mar(3):35-8.
This study is devoted to experimental investigation of using a polymeric self-dissolving film of N-vinylpyrrolidine and alkylmethacrylate 100 muk to 300 muk in width for arthroplasty of the hip joint. The experiments were carried out on 10 rabbits whose articular cartilage from the acetabulum was removed and the latter was lined with the polymeric film. The animals were excluded from the experiment at different periods (from 2 weeks to 8 months). It was morphologically determined that the use of a biocompatible film leads to the formation of a new cartilage or a cartilaginous regenerate, which at later terms is replaced by fibrillar connective tissue and fibrillar cartilage, while the biocompatible film plays no direct role in the formation of the cartilage and the connective tissue, but contributes to their emergence under the latter as if under protector.
本研究致力于对宽度为100微米至300微米的N - 乙烯基吡咯烷和甲基丙烯酸烷基酯聚合物自溶膜用于髋关节置换术进行实验研究。实验在10只兔子身上进行，切除其髋臼的关节软骨，并用聚合物膜覆盖髋臼。在不同时间段（从2周到8个月）将动物排除在实验之外。形态学测定表明，使用生物相容性膜会导致新软骨或软骨再生组织的形成，后期会被纤维结缔组织和纤维软骨取代，而生物相容性膜在软骨和结缔组织的形成中不发挥直接作用，但有助于它们在其下方出现，就好像在保护之下一样。
