克罗卡林（BRL 34915）和二氮嗪可激活胰岛素分泌细胞中的ATP调节钾通道。 - Suppr

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超能文献

Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells.

作者信息

Dunne M J, Yule D I, Gallacher D V, Petersen O H

机构信息

M.R.C. Secretory Control Research Group, University of Liverpool, Great Britain.

出版信息

Pflugers Arch. 1989;414 Suppl 1:S154-5. doi: 10.1007/BF00582279.

DOI:10.1007/BF00582279

PMID:2674892

Abstract

摘要

相似文献

Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells.克罗卡林（BRL 34915）和二氮嗪可激活胰岛素分泌细胞中的ATP调节钾通道。

Pflugers Arch. 1989;414 Suppl 1:S154-5. doi: 10.1007/BF00582279.

Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.二氮嗪和克罗卡林对胰岛素分泌细胞中钾通道的激活作用依赖于细胞内二磷酸腺苷（ADP）以及通道的失活。

Biochem Soc Trans. 1993 Nov;21(4):426S. doi: 10.1042/bst021426s.

Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP.二氮嗪和克罗卡林对培养的大鼠及RINm5F胰岛素分泌细胞中钾通道的激活特性；鸟苷三磷酸的作用

Exp Physiol. 1993 Jan;78(1):25-34. doi: 10.1113/expphysiol.1993.sp003668.

The effects of cromakalim on ATP-sensitive potassium channels in insulin-secreting cells.克罗卡林对胰岛素分泌细胞中ATP敏感性钾通道的作用。

Br J Pharmacol. 1990 Jan;99(1):169-75. doi: 10.1111/j.1476-5381.1990.tb14672.x.

Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells.克罗卡林（BRL 34915）和二氮嗪对胰岛素分泌细胞的膜电位、细胞内钙离子浓度（[Ca2+]i）及ATP敏感性钾电流影响的比较研究

J Membr Biol. 1990 Mar;114(1):53-60. doi: 10.1007/BF01869384.

Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.二氮嗪和克罗卡林与啮齿动物及克隆胰岛素分泌细胞中ATP调节的钾通道的相互作用。

J Mol Endocrinol. 1993 Feb;10(1):59-70. doi: 10.1677/jme.0.0100059.

Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line.二氮嗪对胰岛素分泌细胞系记录的ATP-K+电流的双重作用。

Br J Pharmacol. 1989 Aug;97(4):1039-50. doi: 10.1111/j.1476-5381.1989.tb12560.x.

Effects of putative activators of K+ channels in mouse pancreatic beta-cells.钾通道假定激活剂对小鼠胰腺β细胞的影响。

Br J Pharmacol. 1989 Nov;98(3):957-65. doi: 10.1111/j.1476-5381.1989.tb14626.x.

Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.钾通道假定激活剂对胰腺β细胞功能影响的比较

Pflugers Arch. 1989;414 Suppl 1:S152-3. doi: 10.1007/BF00582278.

Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.格列本脲可阻断血管平滑肌对BRL 34915（克罗卡林）、硫酸米诺地尔和二氮嗪的舒张反应。

J Pharmacol Exp Ther. 1989 Jan;248(1):149-56.

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J Membr Biol. 1993 Mar;132(2):125-36. doi: 10.1007/BF00239002.

Vasopressin directly closes ATP-sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin-secreting cells.血管加压素直接关闭ATP敏感性钾通道，引起膜去极化，并使胰岛素分泌细胞内的游离Ca2+浓度升高。

EMBO J. 1989 Dec 1;8(12):3595-9. doi: 10.1002/j.1460-2075.1989.tb08532.x.

The pharmacology of ATP-sensitive K+ channels in the heart.

Pflugers Arch. 1989;414 Suppl 1:S93-8. doi: 10.1007/BF00582255.

Regulation of K+ channels plays a crucial role in the control of insulin secretion.钾离子通道的调节在胰岛素分泌的控制中起着至关重要的作用。

Pflugers Arch. 1989;414 Suppl 1:S115-20. doi: 10.1007/BF00582259.

Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+.

J Membr Biol. 1990 Feb;113(2):131-8. doi: 10.1007/BF01872887.

Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.克罗卡林、吡那地尔和尼可地尔对5-羟色胺预收缩的大鼠离体基底动脉舒张作用的分析。

Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):377-83. doi: 10.1007/BF00179042.

Alkali cation permeability and caesium blockade of cromakalim-activated current in guinea-pig ventricular myocytes.豚鼠心室肌细胞中克罗卡林激活电流的碱金属阳离子通透性和铯阻断作用

Br J Pharmacol. 1991 Jul;103(3):1795-801. doi: 10.1111/j.1476-5381.1991.tb09865.x.

本文引用的文献

Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.BRL 34915与维拉帕米对大鼠门静脉电活动和机械活动影响的比较。

Br J Pharmacol. 1986 May;88(1):103-11. doi: 10.1111/j.1476-5381.1986.tb09476.x.

Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists.胰岛素分泌中的信号转导：代谢刺激与受体激动剂的比较

Ann N Y Acad Sci. 1986;488:317-33. doi: 10.1111/j.1749-6632.1986.tb46568.x.

The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.钾通道开放剂克罗卡林（BRL 34915）可激活分离的心肌细胞中的ATP依赖性钾通道。

Biochem Biophys Res Commun. 1988 Jul 29;154(2):620-5. doi: 10.1016/0006-291x(88)90184-2.

Interaction of diazoxide, tolbutamide and ATP4- on nucleotide-dependent K+ channels in an insulin-secreting cell line.二氮嗪、甲苯磺丁脲和ATP4-对胰岛素分泌细胞系中核苷酸依赖性钾通道的相互作用。

J Membr Biol. 1987;99(3):215-24. doi: 10.1007/BF01995702.

Electrophysiology of the pancreas.胰腺的电生理学

Physiol Rev. 1987 Jul;67(3):1054-116. doi: 10.1152/physrev.1987.67.3.1054.

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.甲苯磺丁脲和二氮嗪对小鼠胰腺β细胞中ATP依赖性钾通道的相反作用。

Pflugers Arch. 1986 Nov;407(5):493-9. doi: 10.1007/BF00657506.

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