Sforza Chiarella, Dolci Claudia, Rosati Riccardo, de Menezes Marcio, Pisoni Luca, Ferrario Virgilio F, Elamin Fadil
Ital J Anat Embryol. 2014;119(3):201-13.
To investigate dimensions and ratios of soft-tissue facial volumes of adult Northern Sudanese subjects with Down syndrome by using computerized anthropometric measurements.
DESIGN, SETTING, AND PATIENTS: The 3D coordinates of soft-tissue facial landmarks were obtained by a computerized digitizer in 26 Northern Sudanese adult subjects with Down syndrome (18 men, 8 women, aged 17-34 years), and in 99 healthy Northern Sudanese controls (48 women, 51 men) of the same age range. From the landmarks, several facial volumes and volume ratios were calculated. Data were compared to those collected in healthy individuals by computing z-scores.
In subjects with Down syndrome, facial volumes were significantly smaller than in control subjects (Student's t, p < 0.05). The patterns of deviation from the norm were similar in men and women. When compared to controls, subjects with Down syndrome had no differences in nose volume as a fraction of total facial volume and a larger total lip volume as a fraction of total facial volume; within the facial middle third, they had relatively larger upper lip volumes and relatively smaller nose volumes.
The facial soft-tissue structures of subjects with Down syndrome differed from those of normal controls of the same age, sex and ethnic group: a reduced facial size was coupled with specific variations in the nasal and labial regions.
通过计算机人体测量法研究成年苏丹北部唐氏综合征患者面部软组织体积的尺寸和比例。
设计、地点和患者：使用计算机数字化仪获取了26名苏丹北部成年唐氏综合征患者（18名男性，8名女性，年龄17 - 34岁）以及99名同年龄范围的苏丹北部健康对照者（48名女性，51名男性）面部软组织标志点的三维坐标。根据这些标志点计算了几个面部体积和体积比。通过计算z分数将数据与健康个体收集的数据进行比较。
唐氏综合征患者的面部体积明显小于对照者（学生t检验，p < 0.05）。男性和女性偏离正常的模式相似。与对照者相比，唐氏综合征患者面部总体积中鼻子体积所占比例无差异，而嘴唇总体积占面部总体积的比例更大；在面部中三分之一区域，他们的上唇体积相对较大，鼻子体积相对较小。
唐氏综合征患者的面部软组织结构与同年龄、性别和种族的正常对照者不同：面部尺寸减小，同时鼻唇区域存在特定变化。
