Liang Ying, Xie Xin, Chen Lu, Yan Shilun, Ye Xuewei, Anjum Komal, Huang Haocai, Lian Xiaoyuan, Zhang Zhizhen
Ocean College, Zhejiang University, Hangzhou 310058, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Mar Drugs. 2016 Jan 6;14(1):10. doi: 10.3390/md14010010.
Chemical investigation of the cultures of marine Streptomyces sp. 182SMLY led to the discovery of two new polycyclic anthraquinones, which were elucidated as N-acetyl-N-demethylmayamycin (1) and streptoanthraquinone A (2) based on the extensive spectroscopic analysis including 2D NMR, HRESIMS, and an electronic circular dichroism (ECD) calculation. Both anthraquinones remarkably suppressed the proliferation of four different glioma cell lines with IC50 values in a range from 0.5 to 7.3 μM and induced apoptosis in the glioma cells. The ratios of IC50 for normal human astrocytes to IC50 for glioma cells were 6.4-53 for 1 and >14-31 for 2. N-acetyl-N-demethylmayamycin (1) also inhibited the growth of methicillin-resistant Staphylococcus aureus with MIC 20.0 μM.
对海洋链霉菌属菌株182SMLY培养物的化学研究导致发现了两种新的多环蒽醌，基于包括二维核磁共振、高分辨电喷雾电离质谱和电子圆二色光谱（ECD）计算在内的广泛光谱分析，它们被鉴定为N - 乙酰 - N - 去甲基马亚霉素（1）和链霉蒽醌A（2）。这两种蒽醌均显著抑制四种不同胶质瘤细胞系的增殖，IC50值在0.5至7.3 μM范围内，并诱导胶质瘤细胞凋亡。正常人星形胶质细胞的IC50与胶质瘤细胞的IC50之比，化合物1为6.4 - 53，化合物2大于14 - 31。N - 乙酰 - N - 去甲基马亚霉素（1）还以20.0 μM的最低抑菌浓度抑制耐甲氧西林金黄色葡萄球菌的生长。
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