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海洋来源的 sp. ZZ380 中新型生物活性 Penicipyrroether A 和 Pyrrospirone J。

Novel Bioactive Penicipyrroether A and Pyrrospirone J from the Marine-Derived sp. ZZ380.

机构信息

Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

出版信息

Mar Drugs. 2019 May 15;17(5):292. doi: 10.3390/md17050292.

DOI:10.3390/md17050292
PMID:31096582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6562518/
Abstract

The marine-sourced fungus sp. ZZ380 was previously reported to have the ability to produce a series of new pyrrospirone alkaloids. Further investigation on this strain resulted in the isolation and identification of novel penicipyrroether A and pyrrospirone J. Each of them represents the first example of its structural type, with a unique 6/5/6/5 polycyclic fusion that is different from the 6/5/6/6 fused ring system for the reported pyrrospirones. Their structures were elucidated by extensive nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic analyses, electronic circular dichroism (ECD) and C NMR calculations and X-ray single crystal diffraction. Penicipyrroether A showed potent antiproliferative activity against human glioma U87MG and U251 cells with half maximal inhibitory concentration (IC) values of 1.64-5.50 μM and antibacterial inhibitory activity with minimum inhibitory concentration (MIC) values of 1.7 μg/mL against methicillin-resistant and 3.0 μg/mL against .

摘要

先前有报道称，海洋来源的真菌 sp. ZZ380 能够产生一系列新的吡咯并螺旋酮生物碱。对该菌株的进一步研究导致了新型 penicipyrroether A 和 pyrrospirone J 的分离和鉴定。它们每一个都代表其结构类型的第一个例子，具有独特的 6/5/6/5 多环融合，与报道的 pyrrospirones 的 6/5/6/6 融合环系统不同。它们的结构通过广泛的核磁共振 (NMR) 和高分辨率电喷雾电离质谱 (HRESIMS) 光谱分析、电子圆二色 (ECD) 和 13 C NMR 计算以及 X 射线单晶衍射来阐明。Penicipyrroether A 对人神经胶质瘤 U87MG 和 U251 细胞表现出很强的抗增殖活性，半数最大抑制浓度 (IC) 值为 1.64-5.50 μM，对耐甲氧西林的金黄色葡萄球菌的最小抑菌浓度 (MIC) 值为 1.7 μg/mL，对 的 MIC 值为 3.0 μg/mL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/ede91306b981/marinedrugs-17-00292-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/71214f3fb851/marinedrugs-17-00292-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/a063f1e84be2/marinedrugs-17-00292-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/c5bf8ddb0d69/marinedrugs-17-00292-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/5b96f437f075/marinedrugs-17-00292-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/c389851bd379/marinedrugs-17-00292-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/ede91306b981/marinedrugs-17-00292-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/71214f3fb851/marinedrugs-17-00292-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/bd507e3c1476/marinedrugs-17-00292-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/0379430bbaa2/marinedrugs-17-00292-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/a063f1e84be2/marinedrugs-17-00292-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/c5bf8ddb0d69/marinedrugs-17-00292-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/5b96f437f075/marinedrugs-17-00292-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/c389851bd379/marinedrugs-17-00292-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/987a/6562518/ede91306b981/marinedrugs-17-00292-g008.jpg

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2
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9
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