Liu Kai, Yang Ya-Bin, Chen Jin-Lian, Miao Cui-Ping, Wang Qiang, Zhou Hao, Chen You-Wei, Li Yi-Qing, Ding Zhong-Tao, Zhao Li-Xing
Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, People's Republic of China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
Nat Prod Bioprospect. 2016 Feb;6(1):49-55. doi: 10.1007/s13659-015-0085-z. Epub 2016 Jan 11.
Four new fungal polyketides named koninginins N-Q (1-4), together with four known analogues (5-8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity.
从三七内生真菌康宁木霉YIM PH30002中分离得到4个新的真菌聚酮化合物，命名为三七菌素N-Q（1-4），以及4个已知类似物（5-8）。通过光谱数据分析确定了它们的结构。对这些化合物进行了抗真菌活性、一氧化氮抑制活性和抗凝活性的评估。
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