Chen Lin, Wu Guang-Wei, Liu Dong, Zhuang Wen-Ying, Yin Wen-Bing
a State Key Laboratory of Mycology, Institute of Microbiology , Chinese Academy of Sciences , Beijing 100101 , China.
b Zhengzhou Key Laboratory of Medicinal Resources Research, Institute of Nanostructured Functional Materials , Huanghe Science and Technology College , Zhengzhou 450006 , China.
J Asian Nat Prod Res. 2019 Jul;21(7):659-665. doi: 10.1080/10286020.2018.1465051. Epub 2018 Apr 23.
Two new polyketide derivatives, trichodermatides E () and F (), are unprecedented examples of a polyketide with 6/6/6/6 tetracyclic skeleton, together with five known analogs koninginin B (), koninginin D (), 7-O-methylkoninginin D (), koninginins E and F (-), were isolated from the plant endophytic fungus . The structures of these two compounds were determined by NMR data and HR-ESI-MS analysis. The putative biosynthesis of compounds - was presented.
从植物内生真菌中分离出两种新的聚酮化合物衍生物，曲霉菌素E（）和F（），它们是具有6/6/6/6四环骨架的聚酮化合物的前所未有的例子，同时还分离出了五个已知类似物， koninginin B（）、koninginin D（）、7-O-甲基koninginin D（）、koninginins E和F（-）。通过核磁共振数据和高分辨率电喷雾电离质谱分析确定了这两种化合物的结构，并提出了化合物-的可能生物合成途径。
