Weryńska-Kalemba Maria, Filipowska-Grońska Agata, Kalemba Michał, Krajewska Anna, Grzanka Alicja, Bożek Andrzej, Jarząb Jerzy
Chair and Clinical Department of Internal Diseases, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.
Nuclear Medicine and Endocrine Oncology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
Postepy Dermatol Alergol. 2016 Feb;33(1):18-22. doi: 10.5114/pdia.2014.44015. Epub 2016 Feb 29.
Psoriasis is a chronic and recurrent inflammatory skin disease. The aetiology is still unknown in spite of numerous scientific researches. There is very little evidence which does not provide enough knowledge about allergic reactions in psoriatic patients. Based on the fact that the epidermal barrier damage allows different allergen types to penetrate into deep layers of epidermis and skin, we can assume that it may lead to immunological reactions.
To investigate the allergic reaction indicators and hypersensitivity assessment about contact, inhalant and food allergens. The results were analysed with regard to clinical disease indicators and progression stage of dermal lesions.
Eighty patients with psoriasis were examined. The concentration of total IgE antibodies and allergen specific IgE antibodies (asIgE) were analysed. Standard epidermal tests and atopy patch tests were performed. All the patients were estimated for their dermatological condition based on the PASI scale. The control group consisted of 50 patients without psoriasis and allergic history.
Significantly higher concentration of total E immunoglobulin has been stated in the patients with psoriasis. Higher concentrations of specific allergic IgE antibodies were more often observed in the examined group but the most frequently observed values were present in 1-3 class. The most common airborne allergens were birch, artemisia, timothy and rye pollens. There have not been any significant statistical differences in the case of positive epidermal test results.
There is slightly expressed hypersensitivity in psoriatic patients. This hypersensitivity degree correlates with the intensification of symptoms.
银屑病是一种慢性复发性炎症性皮肤病。尽管进行了大量科学研究，但其病因仍不明确。几乎没有证据能充分说明银屑病患者的过敏反应情况。基于表皮屏障受损会使不同类型的过敏原渗透到表皮深层和皮肤这一事实，我们可以推测这可能会引发免疫反应。
研究接触性、吸入性和食物性过敏原的过敏反应指标及超敏反应评估。并结合临床疾病指标和皮肤病变进展阶段对结果进行分析。
对80例银屑病患者进行检查。分析总IgE抗体和过敏原特异性IgE抗体（asIgE）的浓度。进行标准表皮试验和特应性斑贴试验。所有患者均根据银屑病面积和严重程度指数（PASI）量表评估其皮肤病状况。对照组由50例无银屑病且无过敏史的患者组成。
银屑病患者中总E免疫球蛋白浓度显著更高。在受检组中更常观察到较高浓度的特异性过敏IgE抗体，但最常观察到的值出现在1 - 3级。最常见的空气传播过敏原是桦树、蒿属、梯牧草和黑麦花粉。表皮试验阳性结果方面未发现任何显著的统计学差异。
银屑病患者存在轻度超敏反应。这种超敏反应程度与症状加重相关。
