Mane Rajendra S, Bhanage Bhalchandra M
Department of Chemistry, Institute of Chemical Technology , Mumbai 400019, India.
J Org Chem. 2016 Feb 5;81(3):1223-8. doi: 10.1021/acs.joc.5b02385. Epub 2016 Jan 21.
This work reports oxidative N-dealkylation/carbonylation of tertiary amines to tertiary amides by using molecular oxygen as a sole oxidant using a Pd/C catalyst. This protocol is free from ligands, additives, bases, and cocatalysts. Different tertiary amines as well as aryl iodides have been examined for this transformation, providing desired products in good to excellent yield.
本研究报道了以分子氧作为唯一氧化剂，使用钯碳催化剂将叔胺氧化N-脱烷基化/羰基化生成叔酰胺的反应。该方法无需配体、添加剂、碱和助催化剂。已对不同的叔胺以及芳基碘化物进行了该转化反应的研究，以良好至优异的产率得到了所需产物。
