音猬因子（Shh）信号通路在膀胱癌干性和肿瘤发生中的作用
Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis.
作者信息
Syed Islam S, Pedram Akbari, Farhat Walid A
机构信息
Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Cancer Biology and Experimental Therapeutic Section, Division of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
出版信息
Curr Urol Rep. 2016 Feb;17(2):11. doi: 10.1007/s11934-015-0568-9.
Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is uncertain. Additionally, epithelial-to-mesenchymal transition (EMT) has been identified to promote bladder cancer progression in the initial stages and also contribute to drug resistance in the later stage and ultimately metastasis. We speculate that epithelial-to-mesenchymal transitions (EMT) and Shh fuel the carcinogenesis process. This review presents the most recent studies focusing on the role of Shh signaling in bladder cancer progression.
音猬因子（Shh）信号通路已成为膀胱发育、癌症起始和进展的关键组成部分。虽然Shh信号在膀胱发育中的作用已有充分记录，但其在膀胱癌进展中的作用尚不确定。此外，上皮-间质转化（EMT）已被证实可在初始阶段促进膀胱癌进展，在后期还会导致耐药性并最终引发转移。我们推测上皮-间质转化（EMT）和Shh推动了致癌过程。本综述介绍了聚焦于Shh信号在膀胱癌进展中作用的最新研究。
Zotero 插件