King Abdullah International Medical Research Centre,, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Pathol Oncol Res. 2019 Jul;25(3):1067-1073. doi: 10.1007/s12253-018-0477-6. Epub 2018 Oct 25.
Bladder cancer (BC) is a deadly disease characterized by high recurrence rates and frequent progression to an aggressive phenotype. Dysregulation of various signaling pathways have been implicated in BC tumorigenesis, however, the clinical relevance of sonic hedgehog pathway (Shh) remains under investigated. The aim of the current study was to analyze the prognostic value of Shh expression in patients with bladder carcinoma. Immunohistochemical expression of Shh was performed using tissue microarray with 128 specimens from bladder cancer patients. Kaplan-meier survival was analysed and correlation between Shh protein expression and patients' clinicopathological parameters wasexamined using Fisher's exact test. The immuno-staining results revealed that Shh protein exhibits cytoplasmic localization and is expressed in 49% of the analyzed bladder cancer cohort. Our data indicated that high Shh expression significantly correlated with increased lymph node metastasis (p = 0.02), however no association was reported between Shh expression and other clinicopatholigical parameters. High expression of sonic hedgehog was associated with lymph node invasion which may indicate that Shh might play an important role in progression and metastasis of bladder cancer.
膀胱癌（BC）是一种具有高复发率和频繁向侵袭性表型进展特征的致命疾病。各种信号通路的失调被认为与膀胱癌的发生有关，然而，声波刺猬通路（Shh）的临床相关性仍未得到充分研究。本研究旨在分析 Shh 表达在膀胱癌患者中的预后价值。使用包含 128 例膀胱癌患者的组织微阵列进行 Shh 的免疫组织化学表达分析。采用 Kaplan-Meier 生存分析和 Fisher 确切检验分析 Shh 蛋白表达与患者临床病理参数之间的相关性。免疫染色结果显示，Shh 蛋白表现为细胞质定位，在分析的膀胱癌队列中 49%表达。我们的数据表明，Shh 高表达与淋巴结转移增加显著相关（p=0.02），但 Shh 表达与其他临床病理参数之间没有关联。Shh 的高表达与淋巴结浸润相关，这可能表明 Shh 在膀胱癌的进展和转移中可能发挥重要作用。
