谷氨酰胺摄入对结直肠癌治疗并发症的影响：一项系统综述。
The effect of glutamine intake on complications of colorectal and colon cancer treatment: A systematic review.
作者信息
Jolfaie Nahid Ramezani, Mirzaie Safiye, Ghiasvand Reza, Askari Gholamreza, Miraghajani Maryam
机构信息
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2015 Sep;20(9):910-8. doi: 10.4103/1735-1995.170634.
BACKGROUND
Improvement in complications of antitumor agents and surgery is important to enhance life quality and survival among patients with colon and colorectal cancer. It has been reported that some dietary components such as glutamine (Gln) have beneficial effects on these complications of cancer therapies. However, the results of studies are inconsistent in this area. We performed a review on randomized controlled trials (RCTs) evaluating the effects of Gln intake on complications related to therapeutic strategies of the colon and colorectal cancer.
MATERIALS AND METHODS
A systematic search was conducted in PubMed, Google Scholar, Cochrane Library, and SID databases to find the relevant literature, published before July 2015.
RESULTS
Nine RCTs of 217 screened articles were included in this systematic review. The results of the present review suggested that Gln intake among colon and colorectal cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not provided.
CONCLUSION
The role of Gln intake on some improvement of complications induced by cancer therapeutic methods and shorten the length of hospital stay may be promising and one that is worthy of further exploration.
背景
改善抗肿瘤药物及手术的并发症对于提高结肠癌和直肠癌患者的生活质量及生存率至关重要。据报道，一些饮食成分如谷氨酰胺（Gln）对癌症治疗的这些并发症具有有益作用。然而，该领域的研究结果并不一致。我们对评估摄入Gln对结肠癌和直肠癌治疗策略相关并发症影响的随机对照试验（RCT）进行了综述。
材料与方法
在PubMed、谷歌学术、考克兰图书馆和SID数据库中进行系统检索，以查找2015年7月之前发表的相关文献。
结果
本系统综述纳入了217篇筛选文章中的9项RCT。本综述结果表明，结肠癌和直肠癌患者摄入Gln可减少化疗引起的一些并发症，如肠道粘膜炎和腹泻，并改善氮平衡、免疫系统及术后伤口愈合，而未提及Gln对放化疗副作用的有益作用。
结论
摄入Gln对改善癌症治疗方法引起的一些并发症及缩短住院时间可能具有前景，值得进一步探索。
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