Karimian Jahangir, Hadi Amir, Salehi-Sahlabadi Ammar, Kafeshani Marzieh
Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Clin Nutr Res. 2019 Jul 25;8(3):209-218. doi: 10.7762/cnr.2019.8.3.209. eCollection 2019 Jul.
Colorectal cancer (CRC) is one of the major reasons of mortality in the worldwide. There is clear evidence that some amino acids such as arginine can improve CRC and its complications. Hence, in this systematic review we evaluated the association between arginine intake and CRC improvement. We searched the PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar databases by using proper keywords to find the relevant literatures, published to March 2019. Nine human studies of 523 screened articles were included in present systematic review. The majority of studies have found a positive association between consumption of arginine and CRC improvement. Increased inducible nitric oxide (NO) synthase expression and subsequently increasing the NO concentration in the tumor and/or serum, after arginine intake may be responsible for these protective effects. Also, arginine consumption may reduce cell proliferation in CRC and it can enhance immune function after remove the tumor. Although the benefits of arginine consumption in CRC patients were reported in previous trials, the finding need replication in well-designed studies before final conclusion.
结直肠癌（CRC）是全球主要的死亡原因之一。有明确证据表明，某些氨基酸如精氨酸可改善CRC及其并发症。因此，在本系统评价中，我们评估了精氨酸摄入与CRC改善之间的关联。我们通过使用适当的关键词搜索了PubMed、Scopus、ISI Web of Science、Cochrane图书馆和谷歌学术数据库，以查找截至2019年3月发表的相关文献。本系统评价纳入了对523篇筛选文章的9项人体研究。大多数研究发现精氨酸摄入与CRC改善之间存在正相关。摄入精氨酸后，诱导型一氧化氮（NO）合酶表达增加，随后肿瘤和/或血清中的NO浓度升高，可能是这些保护作用的原因。此外，摄入精氨酸可能会减少CRC中的细胞增殖，并且在切除肿瘤后可以增强免疫功能。尽管先前的试验报道了CRC患者摄入精氨酸的益处，但在得出最终结论之前，这些发现需要在设计良好的研究中进行重复验证。
