Siddhu A, Sud S, Bijlani R L, Karmarkar M G, Nayar U
Department of Physiology, All India Institute of Medical Sciences, New Delhi.
Br J Nutr. 1989 Jul;62(1):131-7. doi: 10.1079/bjn19890013.
The present study was designed to examine the effect of cellulose (CL) on postprandial glycaemia and insulinaemia when ingested with glucose (G), casein (CS) and maize oil (CO) in various combinations. The study was conducted on five healthy male volunteers, on each of whom five meal tolerance tests were performed. The meals were isoenergetic and consisted of G; G and CL; G, CS and CL; G, CO and CL; G, CS, CO and CL. The meals were administered after an overnight fast. In addition to a fasting venous blood sample, blood was collected 0.5, 1.0, 1.5 and 2.0 h after ingestion for measurement of serum glucose and insulin levels. The glycaemic response to G + CS + CL and G + CS + CO + CL was significantly lower, while the insulinaemic response to G + CL was significantly higher than that to G. Addition of CL to G did not alter the glycaemic response, but accentuated the insulinaemic response. Further addition of CS in isoenergetic meals attenuated the glycaemic response, which may be because of a reduction in the amount of G in the meals. Like CS, CL also seemed to have an insulinotropic effect. The mechanism of the insulinotropic effect of CL cannot be deduced from the present study, but it is possible that like G, CL also stimulates gastric inhibitory peptide (GIP) secretion from the duodenum, which in turn stimulates insulin secretion.
本研究旨在探究纤维素（CL）与葡萄糖（G）、酪蛋白（CS）和玉米油（CO）以不同组合摄入时，对餐后血糖和胰岛素血症的影响。该研究以五名健康男性志愿者为对象，对每人进行了五次餐耐量试验。这些餐食能量相等，分别包含：G；G和CL；G、CS和CL；G、CO和CL；G、CS、CO和CL。餐食在禁食一夜后给予。除了采集空腹静脉血样外，在摄入后0.5、1.0、1.5和2.0小时采集血液，以测量血清葡萄糖和胰岛素水平。对G + CS + CL和G + CS + CO + CL的血糖反应显著较低，而对G + CL的胰岛素血症反应显著高于对G的反应。在G中添加CL不会改变血糖反应，但会增强胰岛素血症反应。在等能量餐食中进一步添加CS会减弱血糖反应，这可能是由于餐食中G的量减少所致。与CS一样，CL似乎也具有促胰岛素分泌作用。CL促胰岛素分泌作用的机制无法从本研究中推导得出，但有可能与G一样，CL也刺激十二指肠分泌胃抑制肽（GIP），进而刺激胰岛素分泌。
