通过定量多参数磁共振成像鉴别移行区癌与良性前列腺增生

Differentiating Transition Zone Cancers From Benign Prostatic Hyperplasia by Quantitative Multiparametric Magnetic Resonance Imaging.

作者信息

Elbuluk Osama, Muradyan Naira, Shih Joanna, Bernardo Marcelino, Sankineni Sandeep, Merino Maria J, Wood Bradford J, Pinto Peter A, Choyke Peter L, Turkbey Baris

机构信息

From the *Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD; †iCAD, Inc, Nashua, NH; ‡Division of Cancer Treatment and Diagnosis, Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Imaging Physics, SAIC Frederick, Inc, National Cancer Institute-Frederick, Frederick, MD; and ∥Laboratory of Pathology, ¶Center for Interventional Oncology, and #Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.

出版信息

J Comput Assist Tomogr. 2016 Mar-Apr;40(2):218-24. doi: 10.1097/RCT.0000000000000353.

DOI:10.1097/RCT.0000000000000353

PMID:26760185

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7787362/

Abstract

OBJECTIVE

The aim of this study was to evaluate the value of quantitative diffusion and perfusion parameters to aid in discriminating between transition zone carcinomas and benign prostatic hyperplasia (BPH).

MATERIALS AND METHODS

Twenty-four transition zone cancers and BPH nodules were contoured on T2-weighted magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC) maps, and raw dynamic contrast-enhanced (DCE) MRI. Benign prostatic hyperplasia nodules were then stratified into 2 groups based on the presence or absence of a capsule. Apparent diffusion coefficient values, per-voxel Ktrans, kep, vp, and ve were all compared across all groups.

RESULTS

Average ADCs (×10 mm/s) were 1019.22, 1338.11, and 1272.46 for cancer, encapsulated BPH, and nonencapsulated BPH, respectively. Both subgroups of BPH were found to be significantly different than that of cancer (P < 0.05). No individual DCE-MRI parameter was significantly different between cancer and either BPH group. The area under the curve for ADC alone was 0.83, and no individual DCE imaging parameter improved the area under the curve of ADC.

CONCLUSIONS

Apparent diffusion coefficient may play a role in distinguishing TZ cancers from non-encapsulated BPH nodules that closely resemble cancer.

摘要

目的

本研究旨在评估定量扩散和灌注参数在鉴别移行区癌和良性前列腺增生（BPH）中的价值。

材料与方法

在T2加权磁共振成像（MRI）、表观扩散系数（ADC）图和原始动态对比增强（DCE）MRI上勾勒出24个移行区癌和BPH结节。然后根据有无包膜将良性前列腺增生结节分为2组。比较所有组的表观扩散系数值、每体素的Ktrans、kep、vp和ve。

结果

癌、有包膜BPH和无包膜BPH的平均ADC（×10⁻³mm²/s）分别为1019.22、1338.11和1272.46。发现BPH的两个亚组与癌的平均ADC均有显著差异（P<0.05）。癌与任何一组BPH之间的单个DCE-MRI参数均无显著差异。仅ADC的曲线下面积为0.83，且没有单个DCE成像参数能改善ADC的曲线下面积。