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通过蛋白质组学和转录组学综合分析对人呼吸道合胞病毒与宿主因子相互作用的新见解。

Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis.

作者信息

Dapat Clyde, Oshitani Hitoshi

机构信息

a Department of Virology , Tohoku University Graduate School of Medicine , Sendai , Miyagi Prefecture , Japan.

出版信息

Expert Rev Anti Infect Ther. 2016;14(3):285-97. doi: 10.1586/14787210.2016.1141676. Epub 2016 Feb 3.

DOI:10.1586/14787210.2016.1141676
PMID:26760927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4819838/
Abstract

The lack of vaccine and limited antiviral options against respiratory syncytial virus (RSV) highlights the need for novel therapeutic strategies. One alternative is to develop drugs that target host factors required for viral replication. Several microarray and proteomics studies had been published to identify possible host factors that are affected during RSV replication. In order to obtain a comprehensive understanding of RSV-host interaction, we integrated available proteome and transcriptome datasets and used it to construct a virus-host interaction network. Then, we interrogated the network to identify host factors that are targeted by the virus and we searched for drugs from the DrugBank database that interact with these host factors, which may have potential applications in repositioning for future treatment options of RSV infection.

摘要

针对呼吸道合胞病毒（RSV）缺乏疫苗且抗病毒选择有限，这凸显了新型治疗策略的必要性。一种替代方法是开发针对病毒复制所需宿主因子的药物。已经发表了几项微阵列和蛋白质组学研究，以确定在RSV复制过程中可能受到影响的宿主因子。为了全面了解RSV与宿主的相互作用，我们整合了可用的蛋白质组和转录组数据集，并利用它构建了一个病毒-宿主相互作用网络。然后，我们对该网络进行查询，以识别被病毒靶向的宿主因子，并从药物银行数据库中搜索与这些宿主因子相互作用的药物，这些药物可能在重新定位RSV感染的未来治疗选择方面具有潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/7668400f157d/ierz_a_1141676_f0004_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/c006b610e9f4/ierz_a_1141676_f0001_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/883b99248470/ierz_a_1141676_f0002_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/2084153f81c7/ierz_a_1141676_f0003_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/7668400f157d/ierz_a_1141676_f0004_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/c006b610e9f4/ierz_a_1141676_f0001_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/883b99248470/ierz_a_1141676_f0002_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/2084153f81c7/ierz_a_1141676_f0003_oc.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eea/4819838/7668400f157d/ierz_a_1141676_f0004_oc.jpg

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