Song Wei, Wang Kai, Zhang Run-Jin, Dai Qi-Xin, Zou Shu-Bin
Department of Hepatobiliary Surgery, The Second affiliated hospital of Nanchang University, Nanchang, China -
Minerva Med. 2016 Feb;107(1):70-6. Epub 2016 Jan 13.
Growth arrest-specific 5 (GAS5), a newly discovered long-noncoding RNAs (lncRNAs), has been reported to be down-regulated in multiple cancers. This meta-analysis aims to identify the potential value of GAS5 as a biomarker of cancer metastasis and prognosis.
We searched the MEDLINE, EMBASE and Cochrane Library databases. This meta-analysis collected all relevant studies and explored the association of lncRNA GAS5 with overall survival (OS), lymphnode metastasis (LNM), and distant metastasis (DM).
Four studies were eligible for analysis, which included 328 patients. Meta-analysis revealed that low levels of GAS5 expression could predict poor OS in multiple cancers (pooled Hazard Ratio [HR]: 0.38, 95% confidence interval [CI]: 0.26-0.54, P<0.00001). Moreover, compared with high GAS5 expression, low GAS5 expression was correlated with LNM (pooled HR: 4.03, 95% CI: 1.93-8.41, P=0.0002) and DM (pooled HR: 10.17, 95% CI: 1.26-82.31, P=0.03).
lncRNA GAS5 may potentially serve as a novel biomarker for cancer metastasis and prognosis.
生长停滞特异性转录本5（GAS5）是一种新发现的长链非编码RNA（lncRNA），据报道在多种癌症中表达下调。本荟萃分析旨在确定GAS5作为癌症转移和预后生物标志物的潜在价值。
我们检索了MEDLINE、EMBASE和Cochrane图书馆数据库。本荟萃分析收集了所有相关研究，并探讨了lncRNA GAS5与总生存期（OS）、淋巴结转移（LNM）和远处转移（DM）之间的关联。
四项研究符合分析条件，共纳入328例患者。荟萃分析显示，GAS5低表达可预测多种癌症患者的OS较差（合并风险比[HR]：0.38，95%置信区间[CI]：0.26 - 0.54，P < 0.00001）。此外，与GAS5高表达相比，GAS5低表达与LNM（合并HR：4.03，95% CI：1.93 - 8.41，P = 0.0002）和DM（合并HR：10.17，95% CI：1.26 - 82.31，P = 0.03）相关。
lncRNA GAS5可能作为一种新的癌症转移和预后生物标志物。
Zotero 插件