Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China; Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi province, People's Republic of China.
Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi province, People's Republic of China.
Clin Chim Acta. 2018 Jul;482:224-230. doi: 10.1016/j.cca.2017.07.031. Epub 2017 Aug 2.
It has been reported that HOXA transcript at the distal tip (HOTTIP) is dysregulated in various cancers. We performed this meta-analysis to clarify its promising functions as a prognosis marker in malignant tumors.
The electronic databases, including PubMed, Medline, OVID, Cochrane Library, and Web of Science were searched from inception to September 23, 2016. The hazard ratio (HR) and 95% confidence interval (CI) were calculated to explore the relationship between HOTTIP expression and overall survival (OS), which were extracted from the eligible studies. The odds ratio (OR) was calculated to assess the association between HOTTIP expression and pathological parameters by using RevMan5.3 software.
Seven studies were included in the study, with a total of 652 patients. The pooled HR suggested that high HOTTIP expression was significantly correlated with poor OS (HR=2.16, 95% CI: 1.69-2.76, P<0.00001) in cancer patients without obvious heterogeneity. The results showed there was a significant difference in the incidence of lymph node metastasis (LNM) between high HOTTIP expression group and low HOTTIP expression group (OR=2.30, 95% CI: 1.58-3.35, P<0.0001). A similar result was observed in the association between HOTTIP expression and distant metastasis (DM), the odds ratio was 3.30 (95% CI: 1.78-6.12, P=0.0001) without obvious heterogeneity. In addition, high HOTTIP expression was significantly associated with high tumor stage (OR=3.30, 95% CI: 0.25-0.64) without heterogeneity.
This meta-analysis demonstrated that high HOTTIP expression significantly predicts poor OS, lymph node metastasis, distant metastasis and tumor stage, suggesting that high HOTTIP expression may serve as a novel biomarker for poor prognosis in cancers.
已有报道称，HOXA 转录远端末端（HOTTIP）在各种癌症中失调。我们进行了这项荟萃分析，以明确其作为恶性肿瘤预后标志物的有前途的功能。
从开始到 2016 年 9 月 23 日，我们在电子数据库（包括 PubMed、Medline、OVID、Cochrane Library 和 Web of Science）中进行了搜索。使用 RevMan5.3 软件计算风险比（HR）和 95%置信区间（CI），以探索 HOTTIP 表达与总生存期（OS）之间的关系，这些数据是从合格研究中提取的。使用优势比（OR）来评估 HOTTIP 表达与病理参数之间的关联。
共有 7 项研究纳入本研究，共 652 例患者。合并的 HR 表明，在癌症患者中，高 HOTTIP 表达与较差的 OS 显著相关（HR=2.16，95%CI：1.69-2.76，P<0.00001），且无明显异质性。结果表明，高 HOTTIP 表达组与低 HOTTIP 表达组的淋巴结转移（LNM）发生率存在显著差异（OR=2.30，95%CI：1.58-3.35，P<0.0001）。在 HOTTIP 表达与远处转移（DM）之间的关联中也观察到了类似的结果，优势比为 3.30（95%CI：1.78-6.12，P=0.0001），且无明显异质性。此外，高 HOTTIP 表达与高肿瘤分期显著相关（OR=3.30，95%CI：0.25-0.64），且无异质性。
这项荟萃分析表明，高 HOTTIP 表达显著预测 OS 不良、淋巴结转移、远处转移和肿瘤分期，表明高 HOTTIP 表达可能成为癌症不良预后的新型生物标志物。
