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Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival.脂联素受体1可保留二十二碳六烯酸并促进光感受器细胞存活。
Nat Commun. 2015 Mar 4;6:6228. doi: 10.1038/ncomms7228.
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Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies.长链和极长链多不饱和脂肪酸在黄斑变性和营养不良中的作用。
Clin Lipidol. 2011;6(5):593-613. doi: 10.2217/clp.11.41.
3
Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks.导致常染色体显性型 Stargardt 病 3 型的突变 ELOVL4 被错误定位到视杆外节盘。
Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3669-80. doi: 10.1167/iovs.13-13099.
4
Biosynthesis of very long-chain polyunsaturated fatty acids in hepatocytes expressing ELOVL4.肝细胞中 ELOVL4 的表达与非常长链多不饱和脂肪酸的生物合成。
Adv Exp Med Biol. 2014;801:631-6. doi: 10.1007/978-1-4614-3209-8_79.
5
Circulating omega-3 Fatty acids and neovascular age-related macular degeneration.循环中的 omega-3 脂肪酸与新生血管性年龄相关性黄斑变性。
Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2010-9. doi: 10.1167/iovs.14-13916.
6
Comprehensive and sensitive quantification of long-chain and very long-chain polyunsaturated fatty acids in small samples of human and mouse retina.全面且灵敏地定量检测人眼和鼠眼视网膜中小样本中的长链及超长链多不饱和脂肪酸。
J Chromatogr A. 2013 Sep 13;1307:191-200. doi: 10.1016/j.chroma.2013.07.103. Epub 2013 Aug 1.
7
High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation.在哺乳期的第一个月，人乳中抗炎和促解决脂质介质脂氧素和 resolvins 水平升高，二十二碳六烯酸水平下降。
Lipids Health Dis. 2013 Jun 15;12:89. doi: 10.1186/1476-511X-12-89.
8
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.叶黄素+玉米黄质和欧米伽-3 脂肪酸治疗年龄相关性黄斑变性：年龄相关性眼病研究 2（AREDS2）随机临床试验。
JAMA. 2013 May 15;309(19):2005-15. doi: 10.1001/jama.2013.4997.
9
Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.ELOVL4 及超长链多不饱和脂肪酸在 Stargardt 型 3 视网膜变性小鼠模型中的作用。
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5181-6. doi: 10.1073/pnas.1214707110. Epub 2013 Mar 11.
10
Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study.口服二十二碳六烯酸预防渗出性年龄相关性黄斑变性：Nutritional AMD Treatment 2 研究。
Ophthalmology. 2013 Aug;120(8):1619-31. doi: 10.1016/j.ophtha.2013.01.005. Epub 2013 Feb 8.

人类视网膜超长链多不饱和脂肪酸与膳食脂质生物标志物的关联。

Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers.

作者信息

Gorusupudi Aruna, Liu Aihua, Hageman Gregory S, Bernstein Paul S

机构信息

John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132.

John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132 Sharon Eccles Steele Center for Translational Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132.

出版信息

J Lipid Res. 2016 Mar;57(3):499-508. doi: 10.1194/jlr.P065540. Epub 2016 Jan 13.

DOI:10.1194/jlr.P065540
PMID:26764040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4766999/
Abstract

The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. Eyes from age-related macular degeneration (AMD) donors have significantly decreased levels of VLC-PUFAs and low n-3/n-6 ratios. These results are consistent with the protective role of dietary n-3 LC-PUFAs against AMD and emphasize the importance of monitoring systemic biomarkers of lipid intake when undertaking clinical trials of lipid supplements for prevention and treatment of retinal disease.

摘要

众所周知，人类视网膜具有独特的脂质谱，富含长链多不饱和脂肪酸（LC-PUFAs）和极长链多不饱和脂肪酸（VLC-PUFAs），这些脂肪酸似乎有助于维持视网膜的正常结构和功能，但饮食对健康和疾病状态下视网膜脂质谱的影响仍存在争议。在本研究中，我们检查了两个独立的供体眼队列，并将其视网膜脂质谱与脂质摄入的系统生物标志物进行关联。我们发现，血清和红细胞脂质，以及程度较轻的眼眶脂肪，确实是LC-PUFA和VLC-PUFA系列中视网膜脂质含量和n-3/n-6比值的优秀生物标志物。年龄相关性黄斑变性（AMD）供体的眼睛中VLC-PUFAs水平显著降低，n-3/n-6比值也较低。这些结果与膳食n-3 LC-PUFAs对AMD的保护作用一致，并强调在进行脂质补充剂预防和治疗视网膜疾病的临床试验时，监测脂质摄入的系统生物标志物的重要性。