基于人群的原发性开角型青光眼患者 24 小时眼灌注压评估：邯郸眼病研究。

A Population-Based Assessment of 24-Hour Ocular Perfusion Pressure Among Patients With Primary Open Angle Glaucoma: The Handan Eye Study.

机构信息

From the *Clinical and Epidemiological Eye Research Center, The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; †Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China; ‡Wilmer Eye Institute, Johns Hopkins University; §Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and ¶Handan Eye Hospital, Handan, Hebei Province, China.

出版信息

Asia Pac J Ophthalmol (Phila). 2016 Mar-Apr;5(2):127-32. doi: 10.1097/APO.0000000000000155.

DOI:10.1097/APO.0000000000000155

PMID:26765037

Abstract

PURPOSE

To compare the 24-hour ocular perfusion pressure (OPP) among patients with primary open angle glaucoma (POAG) and those with suspected POAG identified in a population-based study in China.

METHODS

Forty-seven patients with POAG and 35 with suspected POAG attended the 24-hour OPP study. Intraocular pressure (IOP) and blood pressure (BP) were measured at 2, 6, and 10 AM and 2, 6, and 10 PM. Subjects were not taking any medications to lower IOP, which was measured with Goldmann applanation in an upright sitting position. Blood pressure was measured in a supine position using a digital automatic BP monitor (OMRON, model HEM-907). Mean arterial pressure was calculated as diastolic BP + 1[Fraction Slash]3 × (systolic BP - diastolic BP). Mean OPP (MOPP) was defined as 2[Fraction Slash]3 × mean arterial pressure - IOP, systolic OPP (SOPP) was defined as 2[Fraction Slash]3 × systolic BP - IOP, and diastolic OPP (DOPP) was defined as 2[Fraction Slash]3 × diastolic BP - IOP.

RESULTS

After adjustment for age, sex, and IOP, the maximum, mean, and minimum SOPP, DOPP, and MOPP were statistically significantly lower in subjects with POAG than in those with suspected POAG (P < 0.05). The minimum MOPP, SOPP, and DOPP occurred from 10 AM to 2 PM in approximately 60% of eyes with POAG and between 20% and 30% of minimum MOPP, SOPP, and DOPP occurred around 10 PM.

CONCLUSIONS

Systolic OPP, DOPP, and MOPP were consistently lower in eyes with POAG than in those with suspected POAG, providing further evidence that OPP plays a role in the development of glaucoma.

摘要

目的

比较在中国人群为基础的研究中确诊的原发性开角型青光眼（POAG）患者与疑似 POAG 患者的 24 小时眼灌注压（OPP）。

方法

47 例 POAG 患者和 35 例疑似 POAG 患者参加了 24 小时 OPP 研究。眼压（IOP）和血压（BP）分别于上午 2、6 和 10 点以及下午 2、6 和 10 点测量。受试者未服用任何降眼压药物，眼压在直立坐姿下使用 Goldmann 压平眼压计测量。血压在仰卧位使用数字自动血压监测仪（欧姆龙，型号 HEM-907）测量。平均动脉压计算为舒张压+1[分数斜线]3×（收缩压-舒张压）。平均 OPP（MOPP）定义为 2[分数斜线]3×平均动脉压-IOP，收缩期 OPP（SOPP）定义为 2[分数斜线]3×收缩压-IOP，舒张期 OPP（DOPP）定义为 2[分数斜线]3×舒张压-IOP。

结果

校正年龄、性别和 IOP 后，POAG 患者的最大、平均和最小 SOPP、DOPP 和 MOPP 均显著低于疑似 POAG 患者（P<0.05）。大约 60%的 POAG 眼的最小 MOPP、SOPP 和 DOPP 发生在上午 10 点至下午 2 点之间，约 20%至 30%的最小 MOPP、SOPP 和 DOPP 发生在晚上 10 点左右。