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用于高钾血症临床管理的钾结合剂

Potassium-Binding Agents for the Clinical Management of Hyperkalemia.

作者信息

Chaitman Martin, Dixit Deepali, Bridgeman Mary Barna

出版信息

P T. 2016 Jan;41(1):43-50.

PMID:26765867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4699486/
Abstract

Use of sodium polystyrene sulfonate (SPS) dominates the long-term treatment of hyperkalemia, but two new agents, sodium zirconium cyclosilicate and the recently FDA-approved patiromer, may offer potential advantages compared with SPS.

摘要

聚苯乙烯磺酸钠(SPS)的使用在高钾血症的长期治疗中占主导地位,但两种新药,环硅酸锆钠和最近获得美国食品药品监督管理局(FDA)批准的帕替罗姆,与SPS相比可能具有潜在优势。

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本文引用的文献

1
Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.聚磺苯乙烯钠散对高钾血症合并糖尿病肾病患者血钾水平的影响:AMEHTYST-DN 随机临床试验。
JAMA. 2015 Jul 14;314(2):151-61. doi: 10.1001/jama.2015.7446.
2
A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient.一项针对慢性肾病患者高钾血症治疗的2期研究表明,选择性钾离子捕获剂ZS-9安全且有效。
Kidney Int. 2015 Aug;88(2):404-11. doi: 10.1038/ki.2014.382. Epub 2015 Feb 4.
3
Characterization of structure and function of ZS-9, a K+ selective ion trap.钾离子选择性离子阱ZS-9的结构与功能表征
PLoS One. 2014 Dec 22;9(12):e114686. doi: 10.1371/journal.pone.0114686. eCollection 2014.
4
Sodium zirconium cyclosilicate in hyperkalemia.硅酸锆钠治疗高钾血症。
N Engl J Med. 2015 Jan 15;372(3):222-31. doi: 10.1056/NEJMoa1411487. Epub 2014 Nov 21.
5
Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors.在接受 RAAS 抑制剂治疗的肾病和高钾血症患者中应用帕替络尔。
N Engl J Med. 2015 Jan 15;372(3):211-21. doi: 10.1056/NEJMoa1410853. Epub 2014 Nov 21.
6
Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial.环硅酸锆钠降低高钾血症门诊患者血钾水平 28 天的疗效:HARMONIZE 随机临床试验。
JAMA. 2014 Dec 3;312(21):2223-33. doi: 10.1001/jama.2014.15688.
7
Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review.使用聚苯乙烯磺酸纳(Kayexalate)的胃肠道不良事件:系统评价。
Am J Med. 2013 Mar;126(3):264.e9-24. doi: 10.1016/j.amjmed.2012.08.016. Epub 2013 Jan 12.
8
Management of hyperkalemia in hospitalized patients.住院患者高钾血症的管理。
Am J Med Sci. 2014 Feb;347(2):93-100. doi: 10.1097/MAJ.0b013e318279b105.
9
Interventions for non-oliguric hyperkalaemia in preterm neonates.早产儿非少尿性高钾血症的干预措施。
Cochrane Database Syst Rev. 2012 May 16;2012(5):CD005257. doi: 10.1002/14651858.CD005257.pub3.
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PEARL-HF: prevention of hyperkalemia in patients with heart failure using a novel polymeric potassium binder, RLY5016.PEARL-HF研究:使用新型聚合钾结合剂RLY5016预防心力衰竭患者高钾血症
Future Cardiol. 2012 Jan;8(1):17-28. doi: 10.2217/fca.11.71.