Zavodnik L B, Lukienko P I, Bushma M I
Farmakol Toksikol. 1989 May-Jun;52(3):95-101.
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical conditions the activity of the hydroxylating (monooxygenase) system of the human liver and, consequently, the state of its main therapeutic-metabolizing function that is undoubtedly important for the optimization of pharmacotherapy.
所呈现的研究结果表明，测定血液或唾液中安替比林浓度动力学以及尿液中其羟基化产物的谱和比例，使得在临床条件下评估人体肝脏羟化（单加氧酶）系统的活性成为可能，从而评估其主要治疗代谢功能的状态，这无疑对优化药物治疗很重要。
