Zavodnik L B, Tsyrkunov V M, Bushma M I, Lukienko P I, Legon'kova L F
Farmakol Toksikol. 1990 Mar-Apr;53(2):50-2.
Administration of diethylnicotinamide (250 mg orally three times for 8 days) to healthy subjects increased antipyrine (AP) elimination from the saliva by 23% and decreased its half-life by 26%. The excretion in the urine of the products of AP hydroxylation 3-carboxymethylantipyrine and nor-antipyrine as well as glucuronides 3-hydroxymethylantipyrine increased. A positive correlation between the dynamics of the excretion of antipyrine metabolites and glucuronic acid was observed. The elimination from blood of bilirubin glucuronides increased. Diethylnicotinamide in therapeutic doses is supposed to stimulate the processes of hydroxylation and glucuronyl conjugation in humans.
给健康受试者口服二乙烟酰胺（250毫克，每日三次，共8天）后，唾液中安替比林（AP）的消除率提高了23%，其半衰期缩短了26%。AP羟基化产物3-羧甲基安替比林和去甲安替比林以及3-羟甲基安替比林葡糖醛酸苷的尿排泄量增加。观察到安替比林代谢物排泄动态与葡糖醛酸之间呈正相关。胆红素葡糖醛酸苷的血液消除率增加。治疗剂量的二乙烟酰胺被认为可刺激人体中的羟基化和葡糖醛酸基结合过程。
