Burdon R H, Rice-Evans C
Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, London.
Free Radic Res Commun. 1989;6(6):345-58. doi: 10.3109/10715768909087918.
The question of whether free radicals or free radical-related species play a role in the modulation of mammalian cell proliferation is examined. Although a positive role for free radicals as specific components of mitogenic pathways is not apparent it is clear that certain free radical-derived species can have a significant modulatory influence on components of major growth signal transduction mechanisms. Free radical-derived species are also involved in the production of prostaglandins which themselves can modulate cell growth. Free radicals themselves appear to have a down regulatory effect on cell proliferation inasmuch as protection from oxidative stress enhances cell proliferation. On the other hand, in certain cases low levels of active oxygen species can enhance cell proliferation.
本文探讨了自由基或与自由基相关的物质是否在哺乳动物细胞增殖的调节中发挥作用。虽然自由基作为促有丝分裂途径的特定组成部分的积极作用并不明显，但很明显，某些自由基衍生的物质可对主要生长信号转导机制的组成部分产生显著的调节影响。自由基衍生的物质还参与前列腺素的产生，而前列腺素本身可调节细胞生长。自由基本身似乎对细胞增殖具有下调作用，因为免受氧化应激的保护可增强细胞增殖。另一方面，在某些情况下，低水平的活性氧可增强细胞增殖。
