Rau R, Höckel S
Fortschr Med. 1989 Jul 30;107(22):485-8.
In this single-blind comparative study 97 patients suffering from activated gonarthrosis were treated with either 4 x 40 mg of diclofenac gel or 4 x 5 mg piroxicam gel. Owing to protocol violations, 28 patients were not included in the statistical evaluation. During the course of the treatment, a marked decrease in signs and symptoms was observed in the 69 patients included in the evaluation. In 80% of the patients, the treating physician assessed the efficacy of piroxicam gel as "good" or "excellent", in only 20% it was assessed as "moderate". In the diclofenac group, assessment of the results was positive in 74% of the patients. In 24% of the patients of this group, the physician's assessment of the success of the treatment was "not satisfactory". The majority of physicians and patients were satisfied with the toleration of the drugs used in this study. Only 2 patients (5.6%) of the piroxicam group and 4 patients (12.2%) of the diclofenac group were critical of local toleration. The results of this clinical trial show that the preparations used here are appropriate for local therapy of distortions of the ankle joint.
在这项单盲对照研究中，97例活动性膝关节炎患者分别接受4×40毫克双氯芬酸凝胶或4×5毫克吡罗昔康凝胶治疗。由于违反方案，28例患者未纳入统计评估。在治疗过程中，纳入评估的69例患者的体征和症状均有显著减轻。80%的患者，治疗医生评估吡罗昔康凝胶疗效为“好”或“优”，仅20%评估为“中等”。在双氯芬酸组，74%的患者对结果评估为阳性。该组24%的患者，医生对治疗效果的评估为“不满意”。大多数医生和患者对本研究中使用药物的耐受性感到满意。吡罗昔康组仅2例患者（5.6%）和双氯芬酸组4例患者（12.2%）对局部耐受性持批评态度。该临床试验结果表明，此处使用的制剂适用于踝关节畸形的局部治疗。
