Arioli G, Scaramelli M, Pillosu W
Servizio di Recupero e Rieducazione Funzionale, U.S.L.L. 49 di Suzzara.
Clin Ter. 1990 Sep 30;134(6):363-9.
An open comparative study on 75 patients with the aim to compare efficacy and safety of two non steroidal antiinflammatory drugs for topic use, piroxicam 1% cream (38 patients) and diclofenac 1% emulgel (37 patients) in the acute musculoskeletal disorders (tendinitis, distortion, muscular disorders etc.) has been carried out. Piroxicam has been administered at the dose of 0.5-1 g cream and diclofenac at the dose of 4 g emulgel, both 4 times a day for a period of 14 days. At baseline, 3rd, 7th and 14th days were evaluated: pain on movement, on pressure, function restriction, and the global evolution of symptomatology; at the end of the treatment the patient gave an evaluation on the physical characteristics of the two drugs, and the physician and the patients gave also global evaluation of efficacy and safety. The statistical analysis of the quantitative data (ANOVA and Student's t-tests) and qualitative data (Wilcoxon's test, chi 2 - and Fisher-tests) showed a significative reduction of pain on movement and of function's capacity at 3rd day, of pain on pressure and of function restriction on 7th day with both drugs with a superiority of piroxicam for some of the above mentioned parameters (7th and 14th days). Also the evaluation of the physical characteristics and the global evaluation of efficacy were more favourable for piroxicam. No adverse systemic or local reactions are reported for both drugs.
对75例患者进行了一项开放性比较研究，旨在比较两种局部使用的非甾体抗炎药——1%吡罗昔康乳膏（38例患者）和1%双氯芬酸乳胶剂（37例患者）治疗急性肌肉骨骼疾病（肌腱炎、扭伤、肌肉疾病等）的疗效和安全性。吡罗昔康的给药剂量为0.5 - 1 g乳膏，双氯芬酸的给药剂量为4 g乳胶剂，均为每日4次，疗程为14天。在基线、第3天、第7天和第14天进行评估：运动时疼痛、按压时疼痛、功能受限情况以及症状的总体演变；治疗结束时，患者对两种药物的物理特性进行评价，医生和患者也对疗效和安全性进行总体评价。对定量数据（方差分析和学生t检验）和定性数据（威尔科克森检验、卡方检验和费舍尔检验）的统计分析表明，两种药物在第3天时运动时疼痛和功能能力均有显著降低，在第7天时按压时疼痛和功能受限均有显著降低，在上述一些参数方面（第7天和第14天）吡罗昔康更具优势。此外，吡罗昔康在物理特性评价和疗效总体评价方面更具优势。两种药物均未报告有不良全身或局部反应。
