University of Manchester, Department of Pharmacy and Pharmaceutical Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
Nanomedicine. 2012 Sep;8 Suppl 1:S5-20. doi: 10.1016/j.nano.2012.07.005. Epub 2012 Jul 27.
The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.
口服给药是最广泛应用和接受的药物传递途径。纳米粒子和微粒子在这个领域中的应用越来越多，以优化药物靶向和生物利用度。经常使用的载体系统要么由聚合物材料构建，要么包含聚合物材料。这些纳米载体的例子包括聚合物纳米粒子、固体脂质纳米载体、自乳化药物传递系统和纳米晶体。本文的目的是描述这些前沿技术，并特别关注这些聚合物在胃肠道系统中的相互作用和命运。
