Rivero-Sanz Elena, Pias-Peleteiro Leticia, Gonzalez-Alvarez Veronica
Department of Neurology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
Department of Neuropaediatrics, Hospital Sant Joan de Déu, Barcelona, Spain.
BMJ Case Rep. 2016 Jan 14;2016:bcr2015213018. doi: 10.1136/bcr-2015-213018.
Transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL syndrome) consists of recurrent headaches with focal neurological signs, which can include motor, sensory and aphasic symptoms. Although considered rare, it is becoming increasingly recognised in clinical practice due to the accumulation of case reports. The pathophysiology remains unclear although changes in the neurovascular resemble those found in migraine, which are thought to be triggered by an infectious process. HaNDL can mimic various serious, including life-threatening, diseases, such as stroke and meningoencephalitis, which is why vigorous tests should be sought before this diagnosis of exclusion can be reached. Treatment is symptomatic and the prognosis is excellent. A literature review of the topic is discussed. We report an adolescent girl who presented with recurrent expressive dysphasia and right-sided hypoaesthesia and moderate occipital headaches who was diagnosed with HaNDL syndrome.
伴有脑脊液淋巴细胞增多症的短暂性头痛和神经功能缺损（HaNDL综合征）表现为反复出现的头痛并伴有局灶性神经体征，这些体征可包括运动、感觉和失语症状。尽管被认为较为罕见，但由于病例报告的积累，在临床实践中其越来越受到认可。尽管神经血管的变化类似于偏头痛中的变化，且认为是由感染过程触发，但病理生理学仍不清楚。HaNDL可模仿各种严重疾病，包括危及生命的疾病，如中风和脑膜脑炎，这就是为什么在做出这种排除性诊断之前应进行全面检查的原因。治疗以对症为主，预后良好。本文讨论了该主题的文献综述。我们报告了一名青少年女性，她反复出现表达性失语、右侧感觉减退和中度枕部头痛，被诊断为HaNDL综合征。
