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人乳头瘤病毒基因分型的临床意义。

Clinical significance of human papillomavirus genotyping.

作者信息

Choi Youn Jin, Park Jong Sup

机构信息

Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

J Gynecol Oncol. 2016 Mar;27(2):e21. doi: 10.3802/jgo.2016.27.e21.

DOI:10.3802/jgo.2016.27.e21
PMID:26768784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4717226/
Abstract

Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great advances have been made in understanding the molecular biology of HPV, and HPV's significance in cervical cancer prevention and management has received increased attention. In this review, we discuss the role of HPV genotyping in cervical cancer by addressing: clinically important issues in HPV virology; the current application of HPV genotyping in clinical medicine; and potential future uses for HPV genotyping.

摘要

宫颈癌是全球女性中第四大常见癌症，人乳头瘤病毒（HPV）是其发生发展的主要致病因素。HPV是一种异质性病毒，高危型HPV的持续感染会导致癌症的发生。近几十年来，在了解HPV分子生物学方面取得了巨大进展，HPV在宫颈癌预防和管理中的重要性也受到了更多关注。在本综述中，我们通过探讨以下内容来讨论HPV基因分型在宫颈癌中的作用：HPV病毒学中的临床重要问题；HPV基因分型在临床医学中的当前应用；以及HPV基因分型未来的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/8b08e6bff537/jgo-27-e21-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/d053cf833003/jgo-27-e21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/fcc087ac3ef3/jgo-27-e21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/8b08e6bff537/jgo-27-e21-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/d053cf833003/jgo-27-e21-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/fcc087ac3ef3/jgo-27-e21-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec0f/4717226/8b08e6bff537/jgo-27-e21-g003.jpg

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