Shimizu Yuji, Sato Shimpei, Koyamatsu Jun, Yamanashi Hirotomo, Nagayoshi Mako, Kadota Koichiro, Tsuruda Kazuto, Hayashida Naomi, Abiru Norio, Yamasaki Hironori, Takamura Noboru, Maeda Takahiro
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Island and Community Medicine , Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Physiol Anthropol. 2016 Jan 14;35:2. doi: 10.1186/s40101-016-0084-8.
Recent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis).
We conducted a cross-sectional study of this association in 272 elderly Japanese men (60-79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI.
Multivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m(2)). The parameter estimates (β) and 95% confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m(2)), and β = 0.04 (-0.25, 0.34) for participants with high BMI (≥23 kg/m(2)).
Serum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m(2)). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.
近期研究证实了骨代谢与血管稳态之间存在关联。然而，尚无研究探讨血清碱性磷酸酶（ALP）（一种骨代谢标志物）与循环未成熟细胞如CD34阳性细胞（一种血管稳态标志物）之间的关系。
我们对272名日本老年男性（60 - 79岁）进行了这项关联的横断面研究。由于低体重指数（BMI）状态是日本中风发病率高的人群的一个已知特征，我们基于BMI进行了分层分析。
经混杂因素调整的多变量线性回归分析显示，血清ALP与循环CD34阳性细胞数量之间存在显著相关性，尤其是对于BMI低（<23 kg/m²）的参与者。血清ALP水平每增加一个标准差（62 IU/L）时，循环CD34阳性细胞计数的参数估计值（β）和95%置信区间（CI）为：总受试者β = 0.25（0.04，0.45）；BMI低（<23 kg/m²）的参与者β = 0.45（0.16，0.75）；BMI高（≥23 kg/m²）的参与者β = 0.04（ - 0.25，0.34）。
在日本老年男性总体人群中，尤其是BMI低（<23 kg/m²）的人群，血清ALP与循环CD34阳性细胞呈正相关。这些发现表明，血清ALP水平可能是评估血管稳态不足风险的有效工具，特别是对于经典心血管危险因素相对较少的参与者。
