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用于小规模体内射频暴露实验的桌面式暴露系统及剂量测定法

Desktop exposure system and dosimetry for small scale in vivo radiofrequency exposure experiments.

作者信息

Gong Yijian, Capstick Myles, Tillmann Thomas, Dasenbrock Clemens, Samaras Theodoros, Kuster Niels

机构信息

IT'IS Foundation, ETH, Zurich, Switzerland.

Information Technology and Electrical Engineering, ETH, Zurich, Switzerland.

出版信息

Bioelectromagnetics. 2016 Jan;37(1):49-61. doi: 10.1002/bem.21950.

DOI:10.1002/bem.21950
PMID:26769169
Abstract

This paper describes a new approach to the risk assessment of exposure from wireless network devices, including an exposure setup and dosimetric assessment for in vivo studies. A novel desktop reverberation chamber has been developed for well-controlled exposure of mice for up to 24 h per day to address the biological impact of human exposure scenarios by wireless networks. The carrier frequency of 2.45 GHz corresponds to one of the major bands used in data communication networks and is modulated by various modulation schemes, including Global System for Mobile Communications (GSM), Universal Mobile Telecommunications System (UMTS), Radio Frequency Identification (RFID), and wireless local area network, etc. The system has been designed to enable exposures of whole-body averaged specific absorption rate (SAR) of up to 15 W/kg for six mice of an average weight of 25 g or of up to 320 V/m incident time-averaged fields under loaded conditions without distortion of the signal. The dosimetry for whole-body SAR and organ-averaged SAR of the exposed mice, with analysis of uncertainty and variation analysis, is assessed. The experimental dosimetry based on temperature measurement agrees well with the numerical dosimetry, with a very good SAR uniformity of 0.4 dB in the chamber. Furthermore, a thermal analysis and measurements were performed to provide better understanding of the temperature load and distribution in the mice during exposure.

摘要

本文描述了一种用于评估无线网络设备暴露风险的新方法,包括体内研究的暴露设置和剂量学评估。已开发出一种新型台式混响室,用于对小鼠进行每天长达24小时的可控暴露,以解决无线网络对人体暴露场景的生物学影响。2.45吉赫兹的载波频率对应于数据通信网络中使用的主要频段之一,并由各种调制方案进行调制,包括全球移动通信系统(GSM)、通用移动通信系统(UMTS)、射频识别(RFID)以及无线局域网等。该系统的设计能够在加载条件下,对平均体重25克的六只小鼠实现高达15瓦/千克的全身平均比吸收率(SAR)暴露,或高达320伏/米的入射时间平均场暴露,且信号无失真。对暴露小鼠的全身SAR和器官平均SAR进行剂量测定,并分析不确定性和变化情况。基于温度测量的实验剂量测定与数值剂量测定结果吻合良好,室内SAR均匀性非常好,为0.4分贝。此外,还进行了热分析和测量,以更好地了解暴露过程中小鼠的温度负荷和分布情况。

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