Energy and thermal regulation during bed rest and spaceflight.

In planning for long-duration (1- to 2-yr) space missions (microgravity), the availability of oxygen, water, and food is critical for survival. If astronauts would consume approximately 3,100 kcal and 2.2 liters of fluid per day, the requirements for a 2-yr flight would be 2,263,000 kcal and 1,606 liters for each astronaut. These estimates, based on limited microgravity simulation and flight data, include 1 h/day of moderate isotonic exercise. Each 30-min/day reduction in exercise training time would save 110,869 kcal and 91 liters of water per year. One daily 5-h extravehicular sortie at an average work rate of 1.7 l/min would require an additional 529,250 kcal and 1,095 liters of water per year. Results from microgravity simulation (bed rest) experiments suggest that 1) there is uncertainty whether basal metabolism is unchanged, 2) submaximal ergometer exercise oxygen uptake appears to be unchanged or lower, and 3) without vigorous exercise training near peak levels, the peak oxygen uptake is definitely reduced. In addition, the equilibrium level of exercise core temperature is elevated excessively by approximately 0.5 degrees C after bed-rest acclimation. Changes in the efficiency of work or metabolism in any or all of these conditions could affect nutritional requirements for long spaceflights. Further research is necessary to elucidate the metabolic factors that would be changed and the energy cost of intra- and extravehicular activity during prolonged exposure to microgravity.