Philip Ana-Maria, Gerendas Bianca S, Zhang Li, Faatz Henrik, Podkowinski Dominika, Bogunovic Hrvoje, Abramoff Michael D, Hagmann Michael, Leitner Roland, Simader Christian, Sonka Milan, Waldstein Sebastian M, Schmidt-Erfurth Ursula
Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of ophthalmology, Medical University of Vienna, Vienna, Austria.
Iowa Institute for Biomedical Imaging, L300 Pappajohn Biomedical Discovery Building, Iowa City, Iowa, USA.
Br J Ophthalmol. 2016 Oct;100(10):1372-6. doi: 10.1136/bjophthalmol-2015-307985. Epub 2016 Jan 14.
BACKGROUND/AIMS: The purpose of the study was to create a standardised protocol for choroidal thickness measurements and to determine whether choroidal thickness measurements made on images obtained by spectral domain optical coherence tomography (SD-OCT) and swept source (SS-) OCT from patients with healthy retina are interchangeable when performed manually or with an automatic algorithm.
36 grid cell measurements for choroidal thickness for each volumetric scan were obtained, which were measured for SD-OCT and SS-OCT with two methods on 18 eyes of healthy volunteers. Manual segmentation by experienced retinal graders from the Vienna Reading Center and automated segmentation on >6300 images of the choroid from both devices were statistically compared.
Model-based comparison between SD-OCT/SS-OCT showed a systematic difference in choroidal thickness of 16.26±0.725 μm (p<0.001) for manual segmentation and 21.55±0.725 μm (p<0.001) for automated segmentation. Comparison of automated with manual segmentations revealed small differences in thickness of -0.68±0.513 μm (p=0.1833). The correlation coefficients for SD-OCT and SS-OCT measures within eyes were 0.975 for manual segmentation and 0.955 for automatic segmentation.
Choroidal thickness measurements of SD-OCT and SS-OCT indicate that these two devices are interchangeable with a trend of choroidal thickness measurements being slightly thicker on SD-OCT with limited clinical relevance. Use of an automated algorithm to segment choroidal thickness was validated in healthy volunteers.
背景/目的：本研究的目的是创建一种标准化的脉络膜厚度测量方案，并确定在手动或使用自动算法时，从健康视网膜患者获得的光谱域光学相干断层扫描（SD-OCT）和扫频源（SS-）OCT图像上进行的脉络膜厚度测量是否可互换。
对每个容积扫描进行36个网格单元的脉络膜厚度测量，在18名健康志愿者的眼睛上用两种方法对SD-OCT和SS-OCT进行测量。对维也纳阅读中心经验丰富的视网膜分级人员进行的手动分割和两种设备对>6300张脉络膜图像进行的自动分割进行统计学比较。
SD-OCT/SS-OCT之间基于模型的比较显示，手动分割时脉络膜厚度的系统差异为16.26±0.725 μm（p<0.001），自动分割时为21.55±0.725 μm（p<0.001）。自动分割与手动分割的比较显示厚度差异较小，为-0.68±0.513 μm（p=0.1833）。眼内SD-OCT和SS-OCT测量的相关系数，手动分割时为0.975，自动分割时为0.955。
SD-OCT和SS-OCT的脉络膜厚度测量表明，这两种设备是可互换的，SD-OCT上脉络膜厚度测量有稍厚的趋势，但临床相关性有限。在健康志愿者中验证了使用自动算法分割脉络膜厚度。
