Qiu Xiaoxin, Hong Yuan, Yang Darong, Xia Man, Zhu Haizhen, Li Qinglong, Xie Hailong, Wu Qunfeng, Liu Chen, Zuo Chaohui
Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South University Changsha, Hunan Province, China.
Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University Changsha, Hunan Province, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17140-50. eCollection 2015.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Interferon-alpha (IFN-α) has recently been recognized to harbor therapeutic potential in prevention and treatment of HCC. IFN-stimulated gene 15 (ISG15) is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Several studies have shown that the overexpression of ISG15 is correlated with multiply tumor types. However, the role of ISG15 in hepatitis B virus (HBV)-related HCC remains undetermined. ISG15 expression was found to be obviously higher in HBV-related HCC tissues than that in non-tumor tissues. ISG15 is a novel prognostic marker for predicting 5-year overall survival of HBV-related HCC patients. Overexpression of ISG15 was associated with clinicopathological characteristics and poor patient outcomes. ISG15 may serve as a novel prognostic marker for HBV-related HCC. Therefore, ISG15 may represent a novel HCC marker with prognostic significance and may be helpful in selecting patients for and predicting response to the treatment of HBV-related HCC.
肝细胞癌（HCC）是全球癌症相关死亡的主要原因。α干扰素（IFN-α）最近被认为在HCC的预防和治疗中具有治疗潜力。IFN刺激基因15（ISG15）是一种类泛素分子，作为对多种微生物和细胞应激刺激的主要反应，它被I型干扰素强烈上调。多项研究表明，ISG15的过表达与多种肿瘤类型相关。然而，ISG15在乙型肝炎病毒（HBV）相关HCC中的作用仍未确定。研究发现，ISG15在HBV相关HCC组织中的表达明显高于非肿瘤组织。ISG15是预测HBV相关HCC患者5年总生存率的新型预后标志物。ISG15的过表达与临床病理特征及患者预后不良相关。ISG15可能作为HBV相关HCC的新型预后标志物。因此，ISG15可能代表一种具有预后意义的新型HCC标志物，可能有助于选择HBV相关HCC患者并预测其对治疗的反应。
