泛素样蛋白 UBL3 或成为癌症治疗的新靶点

A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins-UBL3.

机构信息

Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-Ku, Hamamatsu, Shizuoka 431-3192, Japan.

Department of Radiation Oncology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-Ku, Hamamatsu, Shizuoka 431-3192, Japan.

出版信息

Int J Mol Sci. 2023 Jan 8;24(2):1231. doi: 10.3390/ijms24021231.

DOI:10.3390/ijms24021231

PMID:36674743

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9863382/

Abstract

Ubiquitin-like proteins (Ubls) are involved in a variety of biological processes through the modification of proteins. Dysregulation of Ubl modifications is associated with various diseases, especially cancer. Ubiquitin-like protein 3 (UBL3), a type of Ubl, was revealed to be a key factor in the process of small extracellular vesicle (sEV) protein sorting and major histocompatibility complex class II ubiquitination. A variety of sEV proteins that affects cancer properties has been found to interact with UBL3. An increasing number of studies has implied that UBL3 expression affects cancer cell growth and cancer prognosis. In this review, we provide an overview of the relationship between various Ubls and cancers. We mainly introduce UBL3 and its functions and summarize the current findings of UBL3 and examine its potential as a therapeutic target in cancers.

摘要

泛素样蛋白 (Ubls) 通过修饰蛋白质参与多种生物学过程。Ubl 修饰的失调与各种疾病有关，尤其是癌症。泛素样蛋白 3 (UBL3) 是一种 Ubl，被揭示是小细胞外囊泡 (sEV) 蛋白分拣和主要组织相容性复合体 II 泛素化过程中的关键因素。已经发现多种影响癌症特性的 sEV 蛋白与 UBL3 相互作用。越来越多的研究表明 UBL3 表达影响癌细胞生长和癌症预后。在这篇综述中，我们提供了泛素样蛋白与癌症之间关系的概述。我们主要介绍 UBL3 及其功能，并总结 UBL3 的现有研究结果，探讨其作为癌症治疗靶点的潜力。