红细胞悬液冷藏后血小板功能的变化。
Changes in platelet function following cold storage of RBC suspensions.
作者信息
Dang Qian-Li, Li Jian-Gang, Sun Yang, Jin Zhan-Kui, Gao Ying, Xu Cui-Xiang, Chen Ping, Ma Ting, Yang Jiang-Cun
机构信息
Department of Transfusion Medicine, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710068, China.
Department of Transfusion Medicine, Xi'an No. 4 Hospital Xi'an 710004, China.
出版信息
Int J Clin Exp Med. 2015 Oct 15;8(10):18066-73. eCollection 2015.
OBJECTIVE
To provide a basis for the cold-storage of human platelets as a way to assess changes in platelet function.
METHODS
Red blood cell suspensions (11 U and 50 U) were randomly selected at different storage times (3-28 days) and evidence of platelet activation (CD62P) and thromboelastography (TEG) reaction times were investigated.
RESULTS
After 21 days of storage at 4°C, a large number of activated platelets (PAC1+62P+, PAC1-62P+) within the red blood cell suspension (RBCs) retained their function and had TEG-maximum amplitude (TEG-MA) indices in the normal range.
CONCLUSION
We report that platelets in RBC suspensions retain high activity when stored at 4°C for 21 days. The results provide important information for studies that involve storing platelets under cold conditions.
目的
为人类血小板冷藏提供依据，以此作为评估血小板功能变化的一种方法。
方法
在不同储存时间（3 - 28天）随机选取红细胞悬液（11单位和50单位），研究血小板活化证据（CD62P）和血栓弹力图（TEG）反应时间。
结果
在4℃储存21天后，红细胞悬液（RBCs）中的大量活化血小板（PAC1 + 62P +，PAC1 - 62P +）保留了其功能，且血栓弹力图最大振幅（TEG - MA）指标在正常范围内。
结论
我们报告红细胞悬液中的血小板在4℃储存21天时仍保持高活性。这些结果为涉及在低温条件下储存血小板的研究提供了重要信息。
Zotero 插件