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Potential biomarkers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.2 型糖尿病合并冠心病患者胰岛素抵抗和动脉粥样硬化的潜在生物标志物。
Int J Endocrinol. 2013;2013:698567. doi: 10.1155/2013/698567. Epub 2013 Oct 24.
2
[Expression and localization of vascular endothelial growth factor in the radial artery of the coronary artery bypass grafting patients with diabetes].[血管内皮生长因子在糖尿病冠状动脉搭桥患者桡动脉中的表达及定位]
Zhonghua Wai Ke Za Zhi. 2013 Jul;51(7):623-6.
3
Diabetic retinopathy and vascular endothelial growth factor.糖尿病性视网膜病变与血管内皮生长因子
J Res Med Sci. 2013 Jun;18(6):536.
4
Asymmetric dimethylarginine predicts decline of glucose tolerance in men with stable coronary artery disease: a 4.5-year follow-up study.不对称二甲基精氨酸预测稳定型冠状动脉疾病男性葡萄糖耐量下降：一项 4.5 年随访研究。
Cardiovasc Diabetol. 2013;12:64. doi: 10.1186/1475-2840-12-64.
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Heart of the matter: coronary dysfunction in metabolic syndrome.问题的核心：代谢综合征中的冠状动脉功能障碍。
J Mol Cell Cardiol. 2012 Apr;52(4):848-56. doi: 10.1016/j.yjmcc.2011.06.025. Epub 2011 Jul 13.
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VE-cadherin: at the front, center, and sides of endothelial cell organization and function.血管内皮钙黏蛋白：位于内皮细胞组织和功能的前端、中心和侧面。
Curr Opin Cell Biol. 2010 Oct;22(5):651-8. doi: 10.1016/j.ceb.2010.07.006. Epub 2010 Aug 11.
7
Relaxin is a candidate drug for lung preservation: relaxin-induced protection of rat lungs from ischemia-reperfusion injury.松弛素是一种候选药物，可用于肺保护：松弛素诱导的大鼠肺缺血再灌注损伤保护作用。
J Heart Lung Transplant. 2010 Apr;29(4):454-60. doi: 10.1016/j.healun.2009.09.012. Epub 2009 Dec 24.
8
Endothelial dysfunction in metabolic syndrome: prevalence, pathogenesis and management.代谢综合征中的内皮功能障碍：流行情况、发病机制与管理。
Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):140-6. doi: 10.1016/j.numecd.2009.08.006. Epub 2009 Oct 14.
9
Vascular dysfunction in the diabetic placenta: causes and consequences.糖尿病胎盘血管功能障碍：原因和后果。
J Anat. 2009 Jul;215(1):69-76. doi: 10.1111/j.1469-7580.2009.01098.x.
10
Increased levels of endothelial microparticles CD144 (VE-Cadherin) positives in type 2 diabetic patients with coronary noncalcified plaques evaluated by multidetector computed tomography (MDCT).通过多排螺旋计算机断层扫描（MDCT）评估发现，2型糖尿病合并冠状动脉非钙化斑块患者的内皮微粒CD144（血管内皮钙黏蛋白）阳性水平升高。
Atherosclerosis. 2009 Apr;203(2):429-35. doi: 10.1016/j.atherosclerosis.2008.07.039. Epub 2008 Aug 12.

鉴定血浆血管内皮钙黏蛋白作为2型糖尿病患者冠状动脉疾病的生物标志物。

Identification of plasma vascular endothelia-cadherin as a biomarker for coronary artery disease in Type 2 diabetes mellitus patients.

作者信息

Yan Yan, Chang Qingqing, Li Quanmin, Li Lin, Wang Shuang, Du Ruiqin, Hu Xiaoqiang

机构信息

Department of Endocrinology, The Second Artillary General Hospital of Chinese People's Liberation Army Beijing 100088, China.

出版信息

Int J Clin Exp Med. 2015 Oct 15;8(10):19466-70. eCollection 2015.

PMID:26770593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4694493/
Abstract

OBJECTS

To examine how vascular endothelia (VE)-cadherin plasma levels are correlated with parameters associated with endothelial function such as endothelin-1, nitric oxide, nitric oxide synthase and HbA1c in type 2 diabetic patients with coronary artery disease.

METHODS

VE-cadherin levels were analyzed by enzyme-linked immunosorbent assays. Spearman's correlation and multiple stepwise regression analyses were used to examine the relationship between plasma VE-cadherin and other factors.

RESULTS

By univariate correlation analysis, plasma VE-cadherin levels were significantly associated with age, total cholesterol, triglyceride, hemoglobin A1c, and endothelin-1. Multiple regression analysis (adjusted for age, total cholesterol, and triglyceride) showed that plasma VE-cadherin levels were independently and significantly associated with HbA1c and ET-1. Plasma VE-cadherin levels were significantly highest in patients with diabetes mellitus and coronary artery disease. While patients with diabetes mellitus had higher levels of VE-cadherin compared with healthy subjects.

CONCLUSIONS

This study found that VE-cadherin levels might be a biomarker for some endothelial dysfunction associated with coronary artery disease in type 2 diabetes mellitus.

摘要

目的

研究2型糖尿病合并冠心病患者血管内皮（VE）-钙黏蛋白血浆水平与内皮功能相关参数（如内皮素-1、一氧化氮、一氧化氮合酶和糖化血红蛋白A1c）之间的相关性。

方法

采用酶联免疫吸附测定法分析VE-钙黏蛋白水平。采用Spearman相关性分析和多元逐步回归分析来研究血浆VE-钙黏蛋白与其他因素之间的关系。

结果

单因素相关性分析显示，血浆VE-钙黏蛋白水平与年龄、总胆固醇、甘油三酯、糖化血红蛋白A1c和内皮素-1显著相关。多元回归分析（校正年龄、总胆固醇和甘油三酯后）显示，血浆VE-钙黏蛋白水平与糖化血红蛋白A1c和内皮素-1独立且显著相关。糖尿病合并冠心病患者的血浆VE-钙黏蛋白水平显著最高。糖尿病患者的VE-钙黏蛋白水平高于健康受试者。

结论

本研究发现，VE-钙黏蛋白水平可能是2型糖尿病中与冠心病相关的某些内皮功能障碍的生物标志物。